• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Micromechanical finite element modeling and experimental characterization of the compressive mechanical properties of polycaprolactone:hydroxyapatite composite scaffolds prepared by selective laser sintering for bone tissue engineering
【2h】

Micromechanical finite element modeling and experimental characterization of the compressive mechanical properties of polycaprolactone:hydroxyapatite composite scaffolds prepared by selective laser sintering for bone tissue engineering

机译：聚己内酯压缩力学性能的微机械有限元建模和实验表征：通过选择性激光烧结骨组织工程制备的羟基磷灰石复合支架

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Bioresorbable scaffolds with mechanical properties suitable for bone tissue engineering were fabricated from polycaprolactone (PCL) and hydroxyapatite (HA) by selective laser sintering (SLS) and modeled by finite element analysis (FEA). Both solid gage parts and scaffolds having 1-D, 2-D and 3-D orthogonal, periodic porous architectures were made with 0, 10, 20 and 30% HA by volume. PCL:HA scaffolds manufactured by SLS had nearly full density (99%) in the designed solid regions and had excellent geometric and dimensional control. Through optimization of the SLS process, the compressive moduli for our solid gage parts and scaffolds are the highest reported in the literature for additive manufacturing. The compressive moduli of solid gage parts were 299.3, 311.2, 415.5 and 498.3 MPa for PCL:HA loading at 100:0, 90:10, 80:20 and 70:30 respectively. The compressive effective stiffness tended to increase as the loading of HA was increased and the designed porosity was lowered. In the case of the most 3-D porous scaffold, the compressive modulus more than doubled from 14.9 MPa to 36.2 MPa when changing the material from 100:0 to 70:30 PCL:HA. A micromechanical finite element analysis (FEA) model was developed to investigate the reinforcement effect of HA loading on the compressive modulus of the bulk material. Using a first-principles based approach, the random distribution of HA particles in a solidified PCL matrix was modeled for any loading of HA to predict the bulk mechanical properties of the composites. The bulk mechanical properties were also used for FEA of the scaffold geometries. Results of the FEA were found to be in good agreement with experimental mechanical testing. The development of patient and site-specific composite tissue engineering constructs with tailored properties can be seen as a direct extension of this work on computational design, a priori modeling of mechanical properties and direct digital manufacturing.
机译：通过选择性激光烧结（SLS）制造具有适合于骨组织工程的机械性能的机械性能，并通过有限元分析（FEA）建模，由聚己内酯（PCL）和羟基磷灰石（HA）制造。具有1-D，2-D和3-D正交，用0,10,20和30％Ha体积制备具有1-D，2-D和3-D正交的固体量零件和支架。 PCL：由SLS制造的HA支架在设计的固体区域中具有几乎全密度（99％），并且具有优异的几何和尺寸控制。通过优化SLS工艺，用于我们固体量具和支架的压缩模态是添加剂制造的文献中的最高报道。固体量重量的压缩模量为299.3,311.2,415.5和498.3MPa，用于PCL：HA加载为100：0，90:10，80:20和70:30。随着HA负载增加而增加，倾向于增加的压缩有效刚度且设计的孔隙率降低。在最多的3-D多孔支架的情况下，在将材料从100：0转换为70:30时，压缩模量在14.9MPa至36.2MPa增加到36.2MPa。开发了一种微机械有限元分析（FEA）模型来研究HA负载对散装材料压缩模量的增强效果。使用基于第一原理的方法，用于任何负载HA的固化PCL基质中HA颗粒的随机分布以预测复合材料的体积力学性能。体积机械性能也用于支架几何形状的FEA。发现FEA的结果与实验机械测试一致。具有量身定制特性的患者和现场特异性复合组织工程构建体的开发可以被视为在计算设计上的直接延伸，是机械性能和直接数字制造的先验建模。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号