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首页> 外文期刊>Acta biomaterialia >Micromechanical finite-element modeling and experimental characterization of the compressive mechanical properties of polycaprolactone-hydroxyapatite composite scaffolds prepared by selective laser sintering for bone tissue engineering
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Micromechanical finite-element modeling and experimental characterization of the compressive mechanical properties of polycaprolactone-hydroxyapatite composite scaffolds prepared by selective laser sintering for bone tissue engineering

机译：选择性激光烧结制备骨组织工程聚己内酯-羟基磷灰石复合材料支架的微机械有限元建模和实验表征

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Bioresorbable scaffolds with mechanical properties suitable for bone tissue engineering were fabricated from polycaprolactone (PCL) and hydroxyapatite (HA) by selective laser sintering (SLS) and modeled by finite-element analysis (FEA). Both solid gage parts and scaffolds having 1-D, 2-D and 3-D orthogonal, periodic porous architectures were made with 0, 10, 20 and 30 vol.% HA. PCL:HA scaffolds manufactured by SLS had nearly full density (99%) in the designed solid regions and had excellent geometric and dimensional control. Through optimization of the SLS process, the compressive moduli for our solid gage parts and scaffolds are the highest reported in the literature for additive manufacturing. The compressive moduli of solid gage parts were 299.3, 311.2, 415.5 and 498.3 MPa for PCL:HA loading at 100:0, 90:10, 80:20 and 70:30, respectively. The compressive effective stiffness tended to increase as the loading of HA was increased and the designed porosity was lowered. In the case of the most 3-D porous scaffold, the compressive modulus more than doubled from 14.9 to 36.2 MPa when changing the material from 100:0 to 70:30 PCL:HA. A micromechanical FEA model was developed to investigate the reinforcement effect of HA loading on the compressive modulus of the bulk material. Using a first-principles based approach, the random distribution of HA particles in a solidified PCL matrix was modeled for any HA loading to predict the bulk mechanical properties of the composites. The bulk mechanical properties were also used for FEA of the scaffold geometries. The results of the FEA were found to be in good agreement with experimental mechanical testing. The development of patient- and site-specific composite tissue-engineering constructs with tailored properties can be seen as a direct extension of this work on computational design, a priori modeling of mechanical properties and direct digital manufacturing.
机译：通过选择性激光烧结（SLS）由聚己内酯（PCL）和羟基磷灰石（HA）制成具有适合骨组织工程的机械性能的生物可吸收支架，并通过有限元分析（FEA）进行建模。具有0、10、20和30体积％的HA的固体量具零件和具有1-D，2-D和3-D正交，周期性多孔结构的支架都被制成。 SLS制造的PCL：HA脚手架在设计的实体区域中具有几乎全部的密度（99％），并且具有出色的几何和尺寸控制能力。通过优化SLS工艺，我们的量规零件和脚手架的压缩模量是增材制造文献中报道的最高值。当PCL：HA在100：0、90：10、80：20和70:30加载时，固体应变计零件的压缩模量分别为299.3 MPa，311.2 MPa，415.5 MPa和498.3 MPa。随着HA含量的增加和设计孔隙率的降低，压缩有效刚度趋于增加。对于大多数3-D多孔支架，当将材料从100：0更改为70:30 PCL：HA时，压缩模量从14.9 MPa翻了一倍以上，达到36.2 MPa。建立了微机械有限元分析模型，以研究HA载荷对散装材料压缩模量的增强作用。使用基于第一原理的方法，对固化的PCL基质中HA颗粒的随机分布进行建模，以预测任何HA负载，以预测复合材料的整体机械性能。总体机械性能也用于支架几何形状的有限元分析。发现FEA的结果与实验机械测试非常吻合。具有定制属性的针对患者和特定部位的复合组织工程构造的开发可以看作是这项工作在计算设计，力学性质的先验建模和直接数字制造方面的直接扩展。

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