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SYNTHESIS OF CHIRAL LIGAND WITH PERFLUOROALKYL GROUPS FOR HIGHLY EFFECTIVE ASYMMETRIC SYNTHESIS

机译：高效全不对称合成具有全氟烷基的手性配体

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A symmetric synthesis is one of the most attractive projects in recent organic chemistry, and. many chiral ligands have been synthesized and used for this purpose. We have reported highly effective axially dissymmetric ligands with two chiral fiuoroalkyl carbinol moieties (1)'. Characteristics of 1 are: 1. Axial chirality is controlled by the chirality of the chiral centers; this means that inactive axial isomer is thermally converted to active isomer. 2. Perfluoroalkyl groups stabilize the hydroxyl groups. 3. Perfluoroalkyl groups enhance the acidity of the hydroxyl groups and that of metal coordinated to these hydroxyl groups. This causes enhancement of activity. 4. One with long perfluoroalkyl groups are easily recovered with fluorous solvent and can be reused without purification.

机译：对称合成是最近有机化学中最有吸引力的项目之一。已经合成了许多手性配体并将其用于此目的。我们已经报道了具有两个手性氟烷基甲醇部分的高效轴向不对称配体（1）'。 1的特征是：1.轴向手性受手性中心的手性控制;这意味着无活性的轴向异构体被热转化为活性的异构体。 2.全氟烷基稳定羟基。 3.全氟烷基增强了羟基的酸度以及与这些羟基配位的金属的酸度。这导致活动的增强。 4.具有长的全氟烷基的化合物很容易用氟溶剂回收，无需纯化即可重复使用。

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《Treatise Gist Anthology》|2007年|P.5-7|共3页
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Y. S. Sokeirik; Atsushi Tarui; Kazuyuki Sato; Masaaki Omote; Itsumaro Kumadaki; Akira Ando;
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中图分类氟及其化合物;
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1. Highly Effective Chiral Dipyridylphosphine Ligands:Synthesis, Structural Determination, and Applications in the Ru-Catalyzed Asymmetric Hydrogenation Reactions [J] . Pierluigi Barbaro, Claudio Bianchini Chemtracts . 2001,第5期

机译：高效手性二吡啶基膦配体的合成，结构确定及其在钌催化的不对称加氢反应中的应用
2. Synthesis and structural characterization of a highly effective chiral dipyridylphosphine ligand and its application in the Ru-catalyzed asymmetric hydrogenation of beta-ketoesters [J] . Wu J., Zhou ZY., Yeung CH., Synlett . 2001,第Speca期

机译：高效手性二吡啶基膦配体的合成，结构表征及其在Ru催化的β-酮酸酯不对称加氢中的应用
3. Synthesis of axially dissymmetric ligands with two chiral centers of perfluoroalkyl carbinol moiety, and their application to asymmetric syntheses [J] . Omote M, Sato K, Ando A, Current Organic Synthesis . 2007,第2期

机译：具有两个全氟烷基甲醇部分手性中心的轴向不对称配体的合成及其在不对称合成中的应用
4. SYNTHESIS OF CHIRAL LIGAND WITH PERFLUOROALKYL GROUPS FOR HIGHLY EFFECTIVE ASYMMETRIC SYNTHESIS [C] . Y. S. Sokeirik, Atsushi Tarui, Kazuyuki Sato, Sino-Japanese Symposium on Fluorochemical Industry . 2007

机译：用全氟烷基的手性配体合成高效不对称合成
5. Highly efficient asymmetric synthesis of novel diphosphine ligands with additional chiral centers on the backbone and their applications in asymmetric hydrogenation reactions. [D] . Qiu, Liqin. 2003

机译：在骨架上具有额外手性中心的新型二膦配体的高效不对称合成及其在不对称氢化反应中的应用。
6. Asymmetric Synthesis of 44‐(Difluoro)glutamic Acid via Chiral Ni(II)‐Complexes of Dehydroalanine Schiff Bases. Effect of the Chiral Ligands Structure on the Stereochemical Outcome [O] . Dr. Yoshinori Tokairin, Yuhei Shigeno, Dr. Jianlin Han, 2020

机译：通过脱氢丙氨酸席夫碱的手性Ni（II）-络合物不对称合成44-（二氟）谷氨酸。手性配体结构对立体化学结果的影响
7. Synthesis and structural characterization of a highly effective chiral dipyridylphosphine ligand and its application in the Ru-catalyzed asymmetric hydrogenation of β-ketoesters [O] . Wu, J, Chen, H, Zhou, ZY, 2001

机译：高效手性二吡啶基膦配体的合成，结构表征及其在Ru催化的β-酮酯不对称加氢中的应用

SYNTHESIS OF CHIRAL LIGAND WITH PERFLUOROALKYL GROUPS FOR HIGHLY EFFECTIVE ASYMMETRIC SYNTHESIS

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