Transdermal Permeation of Trimetazidine from Nerodilol-based HPMC Gel Drug ReservoirSystem Across Rat Epidermis

机译：曲美他嗪从基于奈洛地洛的HPMC凝胶药物储库系统中透皮渗透到大鼠表皮

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An HPMC gel drug reservoir system containing selected concentrations of nerodilol was prepared and subjected to in vitro permeation studies across rat epidermis. Nerodilol enhanced the flux of the drug across rat epidermis by about 1.96-times when compared to control. It is concluded from the study that HPMC gel drug reservoir containing 4% w/v of nerodilol showed optimal transdermal drug permeation.

机译：制备了包含选定浓度的奈洛地洛的HPMC凝胶药物储库系统，并进行了大鼠表皮的体外渗透研究。与对照组相比，奈罗地洛使药物穿过大鼠表皮的通量提高了约1.96倍。从该研究得出的结论是，含有4％w / v的奈洛地洛的HPMC凝胶药物储库显示出最佳的透皮药物渗透性。

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《Controlled Release Society Annual Meeting and Exposition》|2007年|P.919-920|共2页
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Yellela S. Krishnaiah; Saleh M. Al-Saidan;
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中图分类生物工程学（生物技术）;
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专利

1. Transdermal permeation of trimetazidine from nerodilol-based HPMC gel drug reservoir system across rat epidermis. [J] . Krishnaiah YS, Al-Saidan SM Medical principles and practice: international journal of the Kuwait University, Health Science Centre . 2008,第1期

机译：曲美他嗪从基于nerodilol的HPMC凝胶药物储库系统中穿过大鼠表皮的透皮渗透。
2. Formulation of an HPMC gel drug reservoir system with ethanol-water as a solvent system and limonene as a penetration enhancer for enhancing in vitro transdermal delivery of nicorandil. [J] . Al Saidan SM, Krishnaiah YS, Chandrasekhar DV, Skin pharmacology and physiology . 2004,第6期

机译：用乙醇-水作为溶剂系统和柠檬烯作为渗透增强剂配制HPMC凝胶药物储库系统，以增强尼可地尔的体外透皮递送。
3. Transdermal enhancement strategy of ketoprofen and teriflunomide: The effect of enhanced drug-drug intermolecular interaction by permeation enhancer on drug release of compound transdermal patch [J] . Liu Chao, Guan Yanli, Tian Qi, International Journal of Pharmaceutics . 2019,第期

机译：酮丙烯和萜状剂的透皮增强策略：渗透增强剂增强药物分子间相互作用对复合透皮贴剂药物释放的影响
4. Transdermal Permeation of Trimetazidine from Nerodilol-based HPMC Gel Drug ReservoirSystem Across Rat Epidermis [C] . Yellela S. Krishnaiah, Saleh M. Al-Saidan Controlled Release Society Annual Meeting and Exposition . 2007

机译：基于硝基硅基HPMC凝胶药物储层对大鼠表皮的透皮渗透
5. Kinetics of transdermal drug permeation and mechanisms of skin permeation enhancement. [D] . Chiang, Chin-Chih. 1987

机译：透皮药物渗透的动力学和皮肤渗透增强的机制。
6. Effects of Carbopol® 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study [O] . Yin Zheng, Wu-Qing Ouyang, Yun-Peng Wei, 1988

机译：Carbopol®934比例对用于局部和透皮给药的纳米乳胶的影响：皮肤渗透研究
7. Effects of Carbopolreg; 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study [O] . Yin Zheng, Wu-Qing Ouyang, Yun-Peng Wei, 2016

机译：Carbopol ® 934比例对纳米乳液凝胶的影响局部和透皮药物递送：皮肤渗透研究

Transdermal Permeation of Trimetazidine from Nerodilol-based HPMC Gel Drug ReservoirSystem Across Rat Epidermis

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