In Vivo MRI Assessment of Knee Cartilage in the Medial Meniscal Tear Model of Osteoarthritis in Rats

机译：大鼠骨关节炎半月板内侧撕裂模型中膝关节软骨的MRI评估

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We present a new approach for quantifying the degradation of knee cartilage in the medial meniscal tear (MMT) model of osteoarthritis in the rat. A statistical strategy was used to guide the selection of a region of interest (ROI) from the images obtained from a pilot study. We hypothesize that this strategy can be used to localize a region of cartilage most vulnerable to MMT-induced damage. In order to test this hypothesis, a longitudinal study was conducted in which knee cartilage thickness in a pre-selected ROI was monitored for three weeks and comparisons were made between MMT and control rats. We observed a significant decrease in cartilage thickness in MMT rats and a significant increase in cartilage thickness in sham-operated rats as early as one week post surgery when compared to pre-surgery measurements.

机译：我们提出一种量化大鼠骨关节炎的内侧半月板撕裂（MMT）模型中膝关节软骨退化的新方法。统计策略用于指导从试验研究获得的图像中选择感兴趣区域（ROI）。我们假设该策略可用于定位最易受MMT诱导损伤的软骨区域。为了检验该假设，进行了一项纵向研究，其中监测了预先选择的ROI中的膝软骨厚度，持续了三周，并在MMT和对照大鼠之间进行了比较。与手术前的测量结果相比，我们观察到MMT大鼠的软骨厚度显着减少，而假手术大鼠的软骨厚度则显着增加。

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《International conference on medical image computing and computer-assisted intervention;MICCAI 2010》|2010年|p.57-64|共8页
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Zhiyong Xie; Serguei Liachenko; Ping-Chun Chiao; Santos Carvajal-Gonzalez; Susan Bove; Thomas Bocan;
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中图分类计算技术、计算机技术;医用物理学;
关键词
osteoarthritis; preclinical MRI; cartilage segmentation; surface registration; thickness statistics;

机译：骨关节炎;临床前MRI软骨分割;表面套准;厚度统计;

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专利

1. MRI description of knee medial collateral ligament abnormalities in the absence of trauma: edema related to osteoarthritis and medial meniscal tears [J] . Wen DY, Propeck T, Kane SM, Magnetic resonance imaging: An International journal of basic research and clinical applications . 2007,第2期

机译：无创伤时膝关节内侧副韧带异常的MRI描述：与骨关节炎和半月板内侧撕裂有关的水肿
2. Middle-aged patients with an MRI-verified medial meniscal tear report symptoms commonly associated with knee osteoarthritis [J] . Kristoffer B Hare, L Stefan Lohmander, Nina Jullum Kise, Acta orthopaedica. . 2017,第6期

机译：经MRI验证的半月板内侧撕裂的中年患者报告了通常与膝骨关节炎相关的症状
3. Baseline radiographic osteoarthritis and semi-quantitatively assessed meniscal damage and extrusion and cartilage damage on MRI is related to quantitatively defined cartilage thickness loss in knee osteoarthritis: the Multicenter Osteoarthritis Study [J] . Guermazi A., Eckstein F., Hayashi D., Osteoarthritis and cartilage . 2015,第12期

机译：基线放射成像骨关节炎和半定量评估的半月板损伤以及MRI上的挤压和软骨损伤与膝骨关节炎中定量定义的软骨厚度损失有关：多中心骨关节炎研究
4. In Vivo MRI Assessment of Knee Cartilage in the Medial Meniscal Tear Model of Osteoarthritis in Rats [C] . Zhiyong Xie, Serguei Liachenko, Ping-Chun Chiao, International Conference on Medical Image Computing and Computer-Assisted Intervention . 2010

机译：在大鼠骨关节炎内侧半月板撕裂模型中的体内MRI评估
5. Hip muscle training and its effects on activity level and knee joint loads in medial compartment knee osteoarthritis. [D] . Daher, Julia Helen. 2010

机译：髋关节肌肉训练及其对内侧舱室膝骨关节炎的活动水平和膝关节负荷的影响。
6. Middle-aged patients with an MRI-verified medial meniscal tear report symptoms commonly associated with knee osteoarthritis [O] . Kristoffer B Hare, L Stefan Lohmander, Nina Jullum Kise, 2017

机译：经MRI验证的半月板内侧撕裂的中年患者报告了通常与膝骨关节炎相关的症状
7. In Vivo MRI Assessment of Knee Cartilage in the Medial Meniscal Tear Model of Osteoarthritis in Rats [O] . Zhiyong Xie, Serguei Liachenko, Ping-chun Chiao, 2014

机译：大鼠骨关节炎内侧半月板撕裂模型中膝关节软骨的体内mRI评估

In Vivo MRI Assessment of Knee Cartilage in the Medial Meniscal Tear Model of Osteoarthritis in Rats

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