Synthesis and characterization of magnetic nanoparticles based on N-palmitoyl-chitosan with potential applications in cancer theranostics

机译：基于N-棕榈酰-壳聚糖的磁性纳米粒子的合成与表征及其在癌症治疗中的潜在应用

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A novel magnetic carrier has been prepared by ionic gelation of N-palmitoyl chitosan with sodium tripolyphosphate, in the presence of magnetite. N-palmitoyl chitosan structure has been confirmed by proton nuclear magnetic resonance (¹H-NMR) and Fourier transform infrared (FT-IR) spectroscopy. Dynamic light scattering measurements showed that magnetic nanoparticles have a hydrodynamic mean diameter of about 150 nm and positive zeta potential. The particles are characterized by high magnetic saturation, superparamagnetic behaviour and exhibit the ability to incorporate a chemoterapeutic agent (Doxorubicin), properties that can be further exploited in cancer theranostics.

机译：在磁铁矿的存在下，通过N-棕榈酰壳聚糖与三聚磷酸钠的离子凝胶化制备了一种新型的磁性载体。 N-棕榈酰壳聚糖的结构已通过质子核磁共振（^{1 H-NMR）和傅立叶变换红外光谱（FT-IR）证实。动态光散射测量表明，磁性纳米颗粒具有约150 nm的流体动力学平均直径和正Zeta电位。颗粒的特征在于高磁饱和度，超顺磁性行为，并具有掺入化学治疗剂（阿霉素）的能力，这些性质可以在癌症治疗学中进一步加以利用。}

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《IEEE International Conference on E-Health and Bioengineering》|2013年|1-4|共4页
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Balan Vera; Butnaru Maria; Verestiuc Liliana;
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N-palmitoyl chitosan; cancer theranostics; ionic gelation; magnetic nanoparticles;

机译：N-棕榈酰壳聚糖;肿瘤治疗;离子胶凝;磁性纳米粒子;

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Synthesis and characterization of magnetic nanoparticles based on N-palmitoyl-chitosan with potential applications in cancer theranostics

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