• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>IEEE International Conference on Nano/Molecular Medicine and Engineering >PHOTON BUDGET ANALYSIS FOR A NOVEL FLUORESCENCE LIFETIME IMAGING MICROSCOPY SYSTEM WITH A MODULATED ELECTRON-MULTIPLIED ALL-SOLID-STATE CAMERA
【24h】

PHOTON BUDGET ANALYSIS FOR A NOVEL FLUORESCENCE LIFETIME IMAGING MICROSCOPY SYSTEM WITH A MODULATED ELECTRON-MULTIPLIED ALL-SOLID-STATE CAMERA

机译：具有调制电子乘以全固态相机的新型荧光寿命成像显微镜系统的光子预算分析

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this paper, a novel fluorescence lifetime imaging microscopy system is proposed that uses a modulated, electron-multiplied, all-solid-state camera (MEM-FLIM). This camera will eliminate the need for an image intensifier through the use of an application-specific charge coupled device (CCD) design. We are designing and building a CCD image sensor that can be modulated at the pixel level and that will have an electron multiplication feature to provide high sensitivity at low-light levels. The proposed design has advantages such as better signal-to-noise ratio (SNR), less geometric distortion, better resolution and low cost. It will be employed in both fluorescence lifetime imaging microscopy (FLIM) and, hopefully, in other biological and medical applications. We describe here the characteristic of our system and present a photon budget analysis for MEM-FLIM. This photon budget is important in order to understand the constraints which will be encountered in design and fabrication of our system.
机译：本文提出了一种新颖的荧光寿命显微镜系统，其使用调制，电子乘以全固态相机（MEM-FLIM）。本相机将通过使用特定于应用专用电荷耦合设备（CCD）设计来消除对图像增强器的需求。我们正在设计和构建CCD图像传感器，可以在像素电平的情况下调制，并且该传感器将具有电子乘法特征，以在低光水平下提供高灵敏度。所提出的设计具有诸如更好的信噪比（SNR），几何失真，更好的分辨率和低成本等优点。它将在荧光寿命显微镜（FLIM）中使用，并且希望在其他生物和医学应用中。我们在这里描述了我们系统的特征，并为Mem-Flim提供了光子预算分析。这种光子预算是重要的，以便了解在我们系统的设计和制造中遇到的约束。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号