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首页> 外文会议>Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Efficacy of Ultrasound Mediated Microbubbles in Diclofenac Gel to Enhance Transdermal Permeation in Rheumatoid Arthritis Induced Rat
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Efficacy of Ultrasound Mediated Microbubbles in Diclofenac Gel to Enhance Transdermal Permeation in Rheumatoid Arthritis Induced Rat

机译：超声介导微泡在双氯芬酸凝胶中的功效提高类风湿性关节炎诱导大鼠透皮渗透

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In previous study in the literature, the effect of ultrasound on the transdermal permeation of the nonsteroidal anti-inflammatory drug, diclofenac has been investigated. Therapeutic ultrasound can increase circulation in the inflamed joint and decrease arthritic pain. Recently, transdermal drug delivery has been demonstrated by ultrasound (US) combining with microbubbles (MBs) contrast agent. In this study, the efficiency of US-MBs mediated diclofenac delivery for adjuvant-induced rheumatoid arthritis (RA) in rats was evaluated. RA was induced by injection of 100 μl Freund's complete adjuvant into the ankle joint in SD male rats (250-300g) and were randomly divided into five groups: (1) control group (C); (2) penetrating diclofenac alone (D); (3) US alone (U); (4) US combined with penetrating diclofenac (DU); (5) US combined with MBs and penetrating diclofenac (DUB). The evaluations of ankle width were performed for 10 days by high frequency (40MHz) US B-mode and color Doppler mode imaging before and after treatment. Longitudinal US images of arthritis induced show synovitis and neovascularity. After treatment, only a little neovascularity has been observed. The recovery rate at 10~(th) day in the group DUB (97.7±2.7 %) was significantly higher than in the group C (1.0±2.7 %), group D (37.5±4.6 %), group U (75.5±4.2 %) and group DU (87.3±5.2 %) (p < 0.05). Our results investigated that the treatments of US and MBs can increase skin permeability to enhance diclofenac sodium delivery and inhibit inflammation of the tissues surrounded the arthritic ankle. In color Doppler imaging, after the combination treatment, the synovial neoangiogenesis in the arthritic area was reduced quickly.
机译：在先前的文献中的研究中，研究了超声对非甾体抗炎药物透皮渗透的影响，已经研究了双氯芬酸。治疗超声可以增加发炎的关节和降低关节炎疼痛的循环。最近，通过超声（US）与微泡（MBS）造影剂组合来证明透皮药物递送。在该研究中，评估了US-MBS介导的大鼠辅助风湿性关节炎（RA）的二氯芬酸递送的效率。通过将100μlFreund的完全佐剂注射到SD雄性大鼠（250-300g）中注射100μlFreund的完全佐剂，随机分为五组：（1）对照组（C）; （2）单独穿透双氯芬酸（d）; （3）我们单独（U）; （4）美国结合渗透的双氯芬（DU）; （5）美国联合MBS并穿透双氯芬酸（配音）。通过高频（40MHz）US B模式和彩色多普勒模式成像在治疗之前和之后进行10天进行踝宽度的评估。纵向美国关节炎诱导的展示性炎和新生血管的图像。治疗后，只观察到了一点新血管。组DUB（97.7±2.7％）的10〜（th）日的回收率显着高于C组（1.0±2.7％），D组（37.5±4.6％），u组（75.5±4.2 ％）和Group DU（87.3±5.2％）（P <0.05）。我们的结果调查了，美国和MBS的治疗可以提高皮肤渗透性，以增强双氯芬酸钠递送，抑制组织围绕关节炎踝关节的炎症。在彩色多普勒成像中，在组合处理之后，迅速减少了关节炎区域中的滑膜新谐振。

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