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首页> 外文会议>International Conference on Biomedical Engineering >Influence of Diclofenac Sodium Loading on Physicochemical and Mechanical Properties of Dual Layer Polyvinyl Alcohol Transdermal Patch
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Influence of Diclofenac Sodium Loading on Physicochemical and Mechanical Properties of Dual Layer Polyvinyl Alcohol Transdermal Patch

机译：双氯芬酸钠负荷对双层聚乙烯醇透皮贴剂物理化学和力学性能的影响

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Transdermal drugs delivery offers many advantages over conventional routes of drug delivery that led to this burgeoning interest in this route in recent years. The aim of this work is to investigate the influence of diclofenac sodium (DS) loaded dual layer PVA patch on physicochemical and mechanical properties. The influence of DS-loaded dual layer PVA patch was employed and characterized using Scanning Electron Microscopy (SEM) to observe the polymeric interaction between PVA cryogel and electrospun nanofiber, the FTIR were used to study the interaction of DS in dual layer PVA patch and tensile strength were tested to study the mechanical properties of the DS-loaded dual layer PVA patch. The results show the polymer interaction between PVA cryogel and electrospun nanofiber were observed. The DS spectra were found separately from PVA matrix. As for mechanical strength the curves of DS-loaded were decreased as the percentage of DS loading increases. These results shows that the dual layer PVA patch can be used as the carrier for transdermal DS delivery.
机译：透皮药物递送提供了近年来在这条路线的常规药物交付路线上提供了许多优势。这项工作的目的是探讨双氯芬酸钠（DS）加载双层PVA贴片对物理化学和机械性能的影响。使用DS负载双层PVA贴剂的影响，并使用扫描电子显微镜（SEM）来观察PVA冷冻胶和Electrom纳米纤维之间的聚合物相互作用，FTIR用于研究DS在双层PVA贴剂和拉伸中的相互作用测试强度以研究DS负载双层PVA贴片的力学性能。结果表明，观察到PVA冷冻胶质和电纺纳米纤维之间的聚合物相互作用。与PVA矩阵分开发现DS光谱。对于机械强度，随着DS负荷的百分比增加，加载的DS负载曲线减少。这些结果表明，双层PVA贴片可用作透皮DS递送的载体。

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