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Preparation and characteristics of diatrizoate meglumine-loaded chitosan microspheres

机译：乙二胺甲葡胺负载壳聚糖微球的制备及表征

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The purpose of the present study is to prepare a diatrizoate meglumine-loaded chitosan microsphere, which could be used to be investigated by ultrasonic imaging technique in vivo and would has water absorption swelling property to dredge the obstruction. Diatrizoate meglumine-loaded chitosan microspheres were prepared by crosslink emulsification process, to use chitosan acetic acid solution as aqueous phase, liquid paraffin as oil phase, Span80 and n-butyl alcohol as surfactant, glutaraldehyde solution as crosslink agent. The effect of ratio of diatrizoate meglumine (ratio of W), the ratio of aqueous to organic phase (W/O ratio), the ratio of Span80 to liquid paraffin and the time of crosslink process were optimized by the single factor experiment and response surface experiment. And the optimum prepared microspheres' appearance, distribution, diameter, zeta potential, thermal performance and release properties were measured and their swelling and development properties were observed. The diatrizoate meglumine-loaded chitosan microspheres had a good shape and uniform distribution by light microscope and transmission electron microscope, with average diameters of 1.53 ??m and average zeta potential of ???19.7 mV; the microspheres had a good sustained release property. And the swelling property of the diatrizoate megiumine-loaded chitosan microspheres varied in different conditions and developed clearly under the ultrasonic imaging technique. This study prepares a kind of diatrizoate meglumine-loaded chitosan microspheres, who can make the microspheres, develop and dredge the obstruction at the same time.
机译：本研究的目的是制备载有乙二酸葡甲胺的壳聚糖微球，该微球可用于体内超声成像技术的研究，并具有吸水溶胀的特性以疏通阻塞物。采用交联乳化法制备了负载有乙二酸葡甲胺的壳聚糖微球，以壳聚糖乙酸溶液为水相，液体石蜡为油相，Span80和正丁醇为表面活性剂，戊二醛溶液为交联剂。通过单因素实验和响应面优化了泛影石酸葡甲胺比率（W的比率），水相与有机相的比率（W / O比率），Span80与液体石蜡的比率以及交联过程的时间。实验。并测定了最佳制备的微球的外观，分布，直径，ζ电势，热性能和释放性能，并观察了它们的溶胀和显影性能。用光学显微镜和透射电子显微镜，负载有乙二酸葡甲胺的壳聚糖微球具有良好的形状和均匀的分布，平均直径为1.53μm，平均ζ电势为19.7mV。微球具有良好的持续释放性能。负载有泛影葡甲胺的壳聚糖微球的溶胀性能在不同条件下发生变化，并且在超声成像技术下得到了明显的发展。本研究制备了一种带有乙二酸葡甲胺的壳聚糖微球，该微球可以同时制造微球，发展和疏通阻塞物。

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