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Preparation and characteristics of diatrizoate meglumine-loaded chitosan microspheres

机译：胶质酸盐含型壳聚糖微球的制备及特征

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The purpose of the present study is to prepare a diatrizoate meglumine-loaded chitosan microsphere, which could be used to be investigated by ultrasonic imaging technique in vivo and would has water absorption swelling property to dredge the obstruction. Diatrizoate meglumine-loaded chitosan microspheres were prepared by crosslink emulsification process, to use chitosan acetic acid solution as aqueous phase, liquid paraffin as oil phase, Span80 and n-butyl alcohol as surfactant, glutaraldehyde solution as crosslink agent. The effect of ratio of diatrizoate meglumine (ratio of W), the ratio of aqueous to organic phase (W/O ratio), the ratio of Span80 to liquid paraffin and the time of crosslink process were optimized by the single factor experiment and response surface experiment. And the optimum prepared microspheres' appearance, distribution, diameter, zeta potential, thermal performance and release properties were measured and their swelling and development properties were observed. The diatrizoate meglumine-loaded chitosan microspheres had a good shape and uniform distribution by light microscope and transmission electron microscope, with average diameters of 1.53 ??m and average zeta potential of ???19.7 mV; the microspheres had a good sustained release property. And the swelling property of the diatrizoate megiumine-loaded chitosan microspheres varied in different conditions and developed clearly under the ultrasonic imaging technique. This study prepares a kind of diatrizoate meglumine-loaded chitosan microspheres, who can make the microspheres, develop and dredge the obstruction at the same time.
机译：本研究的目的是制备一种脱嗪型甲磺酸甲酸甲酸壳聚糖微球，其可用于通过体内超声成像技术研究，并将吸水溶胀性疏通阻塞。通过交联乳化工艺制备脱嗪型浓甲酸壳聚糖微球，以使用壳聚糖乙酸溶液作为水相，液体石蜡作为油相，SPAN80和正丁醇作为表面活性剂，戊二醛溶液作为交联剂。通过单因素实验和响应面优化了脱噻唑酯（W）与有机相（W / O比率）的比例，含水与有机相（W / O比率）的比例，SPAN80与液体石蜡的比率进行了优化实验。测量了最佳制备的微球的外观，分布，直径，Zeta电位，热性能和释放性能，并观察到它们的溶胀和发育性能。脱噻唑酸盐加载的壳聚糖微球通过光学显微镜和透射电子显微镜具有良好的形状和均匀的分布，平均直径为1.53Ω，平均Zeta电位为19.7 mV;微球具有良好的持续释放性。并且脱噻唑酯的溶胀性质在不同条件下变化，在不同的条件下变化，并在超声成像技术下显得明显显然。本研究制备了一种含有一种脱嗪型含有氯浓的壳聚糖微球，其可以使微球，同时发育和疏通阻塞。

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