Aptamers that could bind with specific target have great potential as artificial antibodies for diagnostic applications. However, the DNA folding of conformation may change under different environment conditions, thus affecting their affinity and specificity towards target molecules. In this study, a novel microfluidic system was developed that used single influenza universal aptamer for multiple-type influenza virulent diagnosis under different environment conditions. A nanogold and single-aptamer based microfluidic system was demonstrated for successful detection of influenza viruses. The developed microsystem has a great potential for point-of-care applications.
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