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首页> 外文会议>IEEE Integrated STEM Education Conference >Protein association and nucleotide sequence similarities among human alpha-papillomaviruses
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Protein association and nucleotide sequence similarities among human alpha-papillomaviruses

机译：人类α-乳头瘤病毒之间的蛋白质关联和核苷酸序列相似性

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Human papillomavirus, HPV, is one of the most common sexually transmitted infections in the world, accounting for 50 to 55 percent of all cervical cancers. It is an 8,000 base-pair, latent virus that infects stratified epithelial cells. The Human Papillomavirus Alpha genus strains that contain E5 proteins were compared by E5 protein subtype to depict which E5 proteins are found in cancerous and/or non-cancerous strains. This research also identifies the nucleotide sequence similarity percentages of the cancerous and non-cancerous strains of the Human Papillomavirus Alpha genus. The raw data, which includes the nucleotide sequences and the protein content of the strains, was obtained from the website PaVE: Papillomavirus Genome Database. The E5 Protein Association Network and the Nucleotide Sequence Similarity Percentage Network visualizations were created on ORA, a free network visualization program. The E5 Protein Association Network demonstrates that the E5α protein is the only protein encoded by the cancerous strains, and the majority of the non-cancerous strains contain the E5β protein. The Nucleotide Sequence Similarity Percentage Network illustrates clusters formed after filtering out all links less than 70% similarity, clusters which contain both cancerous and non-cancerous nodes. This indicates that malignancy is not a trait based solely on nucleotide sequence or protein content. This research supports the claim that malignancy of Human Papillomavirus Alpha strains is determined solely by neither protein association nor nucleotide sequence.
机译：人乳头瘤病毒HPV是世界上最常见的性传播感染之一，占所有子宫颈癌的50％至55％。它是一种8,000个碱基对的潜伏病毒，可感染分层的上皮细胞。通过E5蛋白亚型比较了包含E5蛋白的人乳头瘤病毒Alpha属菌株，以描述在癌性和/或非癌性菌株中发现了哪些E5蛋白。这项研究还确定了人类乳头瘤病毒Alpha属癌性和非癌性菌株的核苷酸序列相似性百分比。原始数据，包括菌株的核苷酸序列和蛋白质含量，可从网站PaVE：乳头瘤病毒基因组数据库中获得。在免费的网络可视化程序ORA上创建了E5蛋白质协会网络和核苷酸序列相似性百分比网络可视化。 E5蛋白协会网络证明，E5α蛋白是癌毒株编码的唯一蛋白质，大多数非癌毒株均含有E5β蛋白。核苷酸序列相似性百分比网络说明了在过滤掉所有小于70％相似性的链接后形成的簇，该簇同时包含癌性和非癌性节点。这表明恶性肿瘤不是仅基于核苷酸序列或蛋白质含量的特征。这项研究支持这样的说法，即人乳头瘤病毒Alpha株的恶性仅由蛋白质缔合或核苷酸序列决定。

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