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A Petri Net model to simulate and analyse cerebral folate deficiency and hyperhomocysteinemia effects in Autism Spectrum Disorder

机译:Petri网模型,用于模拟和分析自闭症谱系障碍中的叶酸缺乏和高同型半胱氨酸血症

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Autism spectrum disorder (ASD) is one of the most popular disorders. Many researches and experiments in the world have been conducted to study causes of ASD. It has been proved that ASD is associated with elevated concentrations of homocysteine and low concentrations of cerebral folic acid. Being part of a complex biological system, we can model it to study its behaviour relatively to metabolic causes of ASD and predict the deregulations earlier. We use, in this work, a Petri net extension, called HFPN, in order to model a complex system related to metabolic biological causes of ASD and to analyse effects of some enzymes and metabolites in ASD.
机译:自闭症谱系障碍(ASD)是最流行的障碍之一。世界上已经进行了许多研究和实验来研究ASD的病因。业已证明,ASD与高半胱氨酸浓度升高和脑叶酸浓度降低有关。作为复杂生物系统的一部分,我们可以对其进行建模,以研究其相对于ASD代谢原因的行为,并更早地预测放松管制。在这项工作中,我们使用一个称为HFPN的Petri网扩展名,以对与ASD的代谢生物学原因相关的复杂系统进行建模,并分析ASD中某些酶和代谢产物的作用。

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