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首页> 外文会议>Australasian Fluid Mechanics Society;Australasian fluid mechanics conference >Experimental and numerical study of nasal spray characteristics and its application in a realistic human nasal cavity
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Experimental and numerical study of nasal spray characteristics and its application in a realistic human nasal cavity

机译：鼻喷雾特性的实验和数值研究及其在真实人鼻腔中的应用

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The nasal spray characteristics and its drug delivery efficiency in a realistic human nasal cavity was studied in this paper. Commercial pharmaceutical nasal spray devices were utilized for spray formation under physiologically reasonable actuation force. External spray plume characteristics such as the spray cone angle and break-up length were captured via particle/droplet image analysis (PDIA) approach. Numerical spray simulations were conducted by utilizing those experimental data as boundary conditions, where the nasal spray device was inserted into a realistic adult nasal passage. ğ‘˜âˆ’𜔠SST model was used to predict the transitional turbulence flow. The spray direction was aligned with the centerline of the nasal valve to avoid unnecessary early droplets deposition in the vestibule. Particle delivery efficiencies of selected micro-particle size (5 μm, 10 μm, 15 μm, and 50 μm) were assessed. The results demonstrated that the narrowed vestibule channel structure significantly constrained the development of the spray plume, and considerable amount of particles were blocked due to the limited droplets travelling space. For large sized micro-particles (name the size value), inertia dominates their fly paths, and particles were deposited shortly after releasing, while for the small sized particles (name the size value), they can follow the airflow streamlines and travel further downstream due to the reduced inertia effects; however, more particles would pass through the nasal turbinate and may deposit into the lungs, which is harmful as well. This study demonstrated a combined experimental and numerical approach for the better acknowledgment of nasal spray iterations with realistic human nasal cavity. The proposed combined approach can improve the design of future nasal drug delivery devices, and benefit more patients with elevated drug delivery performance.
机译：本文研究了在现实的人鼻腔中的鼻喷雾特性及其给药效率。利用商业上的鼻腔喷雾装置在生理上合理的驱动力下进行喷雾形成。通过颗粒/液滴图像分析（PDIA）方法捕获外部喷雾羽流特性，例如喷雾锥角和破碎长度。利用这些实验数据作为边界条件进行了数值喷雾模拟，其中将鼻喷雾装置插入现实的成人鼻道中。使用“ S”模型来预测过渡湍流。喷雾方向与鼻瓣的中心线对齐，以避免不必要的早期液滴沉积在前庭中。所选微粒大小（5 µm，10 µm，15 µm和50 µm）的粒子传递效率进行了评估。结果表明，狭窄的前庭通道结构极大地限制了喷雾羽流的形成，并且由于有限的液滴行进空间而阻塞了相当数量的颗粒。对于大尺寸微粒（称为尺寸值），惯性控制其飞行路径，并且释放后不久便沉积了颗粒，而对于小尺寸微粒（称为尺寸值），它们可以跟随气流流线并向下游移动由于减少了惯性效应;但是，更多的颗粒会穿过鼻甲，并可能沉积到肺部，这也是有害的。这项研究展示了一种结合实验和数值方法的方法，可以更好地认识具有真实人鼻腔的鼻喷雾剂。所提出的组合方法可以改善未来鼻腔药物输送装置的设计，并使更多具有较高药物输送性能的患者受益。

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