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Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity

机译：鼻给药装置及其取向对现实人鼻腔喷雾颗粒沉积的影响

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In this study, the effects of nasal drug delivery device and the spray nozzle orientation on sprayed droplets deposition in a realistic human nasal cavity were numerically studied. Prior to performing the numerical investigation, an in-house designed automated actuation system representing mean adults actuation force was developed to produce realistic spray plume. Then, the spray plume development was filmed by high speed photography system, and spray characteristics such as spray cone angle, break-up length, and average droplet velocity were obtained through off-line image analysis. Continuing studies utilizing those experimental data as boundary conditions were applied in the following numerical spray simulations using a commercially available nasal spray device, which was inserted into a realistic adult nasal passage with external facial features. Through varying the particle releasing direction, the deposition fractions of selected particle sizes on the main nasal passage for targeted drug delivery were compared. The results demonstrated that the middle spray direction showed superior spray efficiency compared with upper or lower directions, and the 10 gm agents were the most suitable particle size as the majority of sprayed agents can be delivered to the targeted area, the main passage. This study elaborates a comprehensive approach to better understand nasal spray mechanism and evaluate its performance for existing nasal delivery practices. Results of this study can assist the pharmaceutical industry to improve the current design of nasal drug delivery device and ultimately benefit more patients through optimized medications delivery. (C) 2016 Elsevier Ltd. All rights reserved.
机译：在这项研究中，数值研究了鼻腔给药装置和喷嘴方向对实际人鼻腔内喷雾液滴沉积的影响。在进行数值研究之前，开发了代表平均成年人驱动力的内部设计的自动驱动系统，以产生逼真的喷雾羽。然后，通过高速摄影系统对喷雾羽状显影进行拍摄，并通过离线图像分析获得喷雾特性，例如喷雾锥角，破碎长度和平均液滴速度。在随后的数值喷雾模拟中，使用市售的鼻喷雾器将利用这些实验数据作为边界条件进行的持续研究应用到了实际的具有外部面部特征的成人鼻道中。通过改变颗粒的释放方向，比较了用于鼻腔靶向药物输送的主要鼻腔通道上选定粒径的沉积分数。结果表明，与上，下方向相比，中部喷涂方向显示出更高的喷涂效率，并且10 gm药剂是最合适的粒径，因为大多数喷涂剂可以输送到目标区域，即主要通道。这项研究阐述了一种全面的方法，可以更好地了解鼻喷雾剂的作用机制，并评估其在现有鼻腔给药实践中的性能。这项研究的结果可以帮助制药业改善目前鼻腔给药装置的设计，并通过优化药物给药最终使更多患者受益。 （C）2016 Elsevier Ltd.保留所有权利。

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