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首页> 外文会议>Annual conference of the International Society of Exposure Science >Effect of Varying Vapor Pressure Bands on Inhalation Exposure in REACH Consumer Exposure Modelling Tools
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Effect of Varying Vapor Pressure Bands on Inhalation Exposure in REACH Consumer Exposure Modelling Tools

机译：在REACH消费者暴露建模工具中，变化的蒸汽压力带对吸入暴露的影响

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Vapor pressure (VP) bands have been applied in several screening level exposure tools to estimate human inhalation exposure. The VP bands use conservative assumptions relating to how much of a substance in a product/article is likely to be released into air based on its vapor pressure during 'standard' applications. For example, the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) Target Risk Assessment (TRA) consumer module assumes that 100% of a substance will be released to air if its VP is >10Pa. A substance with VP<10Pa will only release a fraction of the substance into the air. To better understand the most appropriate use of consumer exposure predictive tools that use this banding approach (e.g. ECETOC TRA and The European Solvents Industry Group (ESIG) Generic Exposure Scenario (GES) Risk and Exposure Tool (EGRET)), it is necessary to describe the level of conservatism of the current VP bands and their specificity (whether they provide sufficient discrimination for different exposure scenarios). The ECETOC TRA and EGRET consumer exposure models have been compared with the predictions of a higher tier consumer model (ConsExpo) for multiple exposure scenarios and multiple VP bands. The comparisons have been extended to include measured data from a range of consumer scenarios where solvents are used. This analysis confirms the inherent conservatism of the banding approach also suggests a potential refinement for substances at medium high VP range by introducing an additional VP band.
机译：蒸气压（VP）带已应用于几种筛查水平的暴露工具中，以估计人体吸入暴露量。 VP频段使用保守的假设，即基于“标准”应用中产品/物品中的某种物质可能根据其蒸气压释放到空气中的情况。例如，欧洲生态毒理学和化学毒理学中心（ECETOC）目标风险评估（TRA）消费者模块假设，如果VP值> 10Pa，则100％的物质会释放到空气中。 VP <10Pa的物质只会将一部分物质释放到空气中。为了更好地了解使用这种分类方法的消费者暴露预测工具的最适当用法（例如ECETOC TRA和欧洲溶剂工业集团（ESIG）通用暴露场景（GES）风险和暴露工具（EGRET）），有必要描述当前VP频段的保守程度及其特异性（是否为不同的暴露场景提供了足够的区分度）。已将ECETOC TRA和EGRET消费者暴露模型与针对多个暴露场景和多个VP频段的更高层消费者模型（ConsExpo）的预测进行了比较。比较已经扩展到包括来自使用溶剂的一系列消费者场景的测量数据。该分析证实了分带方法的固有保守性，并且还建议通过引入额外的VP带，对中等高VP范围的物质进行潜在的改进。

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