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SPACE SIMULATED MISSIONS AND IMMUNITY: SALIVARY BASED DIAGNOSTIC

机译：空间模拟的任务和免疫力：基于唾液的诊断

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Space agencies are accountable for critical health issues especially on immunity that will be experienced by space personnel during short and long missions away from the Earth. Ground based activities are used to study space related issues and to prepare the astronauts as much as possible for the health burdens including compromised immunity associated with long duration space missions. Few studies were conducted on effects of space environments on immunity. So,This study was conducted to establish effect of a simulated microgravity (HDT bed rest) on immunity by using levels of Epstein Barr Virus , Cortisol, norepinephrine, epinephrine, neuropeptide Y, Substance P and amylase.. The 10 healthy male volunteers were studied before, during, just after, and after 6 weeks of the simulated microgravity condition of -6 head-down-tilt (HDT) bed rest. Saliva samples were taken before, during, just after, and after 6 weeks. Epstein Barr Virus , Cortisol, norepinephrine, epinephrine, neuropeptide Y, Substance P and amylase were measured in standardized ways. Levels of . Epstein Barr Virus , Cortisol, norepinephrine, epinephrine, neuropeptide Y, Substance P and amylase were significantly changed after 6 weeks as compared to before mission. This pilot study indicates that an adverse health on human body in simulated microgravity due to an impaired immune system. So, proper maintaining immune system during long duration missions might be needed to make mission success.
机译：航天机构应对重大的健康问题负责，特别是在短期和长期的离地球任务中，航天人员将经历的免疫力问题。地面活动被用于研究与太空有关的问题，并尽可能使宇航员做好应对健康负担的准备，其中包括与长时间太空飞行有关的免疫力受损。关于空间环境对免疫力影响的研究很少。因此，本研究旨在通过使用爱泼斯坦巴尔病毒，皮质醇，去甲肾上腺素，肾上腺素，神经肽Y，P物质和淀粉酶的水平来建立模拟微重力（HDT卧床休息）对免疫力的影响。研究了10名健康男性志愿者。在-6头向下倾斜（HDT）卧床休息的模拟微重力状态之前，之中，之后和之后6周。在6周之前，之中，之后和之后采集唾液样品。以标准化方式测量了爱泼斯坦巴尔病毒，皮质醇，去甲肾上腺素，肾上腺素，神经肽Y，P物质和淀粉酶。的水平。与任务前相比，爱泼斯坦巴尔病毒，皮质醇，去甲肾上腺素，肾上腺素，神经肽Y，P物质和淀粉酶均在6周后发生了显着变化。这项初步研究表明，由于免疫系统受损，模拟微重力对人体有害。因此，可能需要在长期任务期间适当地维持免疫系统，才能使任务成功。

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