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首页> 外文会议>International Conference on Solid-State Sensors, Actuators and Microsystems >A high throughput photosensitive polymer cantilever integrated with microelectrode array for drug-induced cardiac toxicity screening
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A high throughput photosensitive polymer cantilever integrated with microelectrode array for drug-induced cardiac toxicity screening

机译：高通量光敏聚合物悬臂与微电极阵列集成，用于药物诱导的心脏毒性筛查

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This paper presents a high throughput photosensitive polymer cantilever device for real time monitor of drug-induced cardiac toxicity screening. The cantilever device comprises micro-grooves and 3×3 microelectrode array on top of its surface. The optimized micro-grooves facilitate alignment of cardiomyocytes and thus greatly increase the contraction force generated by the cardiomyocytes. Furthermore, the 3×3 microelectrode array is utilized to record the extracellular impedance of the cardiomyocytes. This method employed to measure both the mechanical and electrical performances of cardiomyocytes was put forward for the first time. The fabricated photosensitive polymer cantilever integrated with microelectrode array is effective to embody the contraction force and impedance of cardiomyocytes simultaneously. We demonstrate that the proposed device has the ability to identify the relationship between contraction force and cell impedance. The assay results indicate that the combining effect of contraction force and cell impedance provides a depth understanding of the drug effect on cardiomyocytes.
机译：本文提出了一种高通量的光敏聚合物悬臂装置，用于实时监测药物诱导的心脏毒性筛查。悬臂装置在其表面顶部包括微沟槽和3×3微电极阵列。优化的微槽有助于心肌细胞的排列，因此大大增加了心肌细胞产生的收缩力。此外，利用3×3微电极阵列来记录心肌细胞的细胞外阻抗。首次提出了用于测量心肌细胞机械和电气性能的方法。所制备的与微电极阵列集成的光敏聚合物悬臂梁可有效地同时体现心肌细胞的收缩力和阻抗。我们证明提出的设备具有识别收缩力和细胞阻抗之间的关系的能力。分析结果表明，收缩力和细胞阻抗的结合作用提供了对药物对心肌细胞作用的深入了解。

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