Correlation between Mutation Pressure, Selection Pressure, and Occurrence of Ammo Acids

机译：突变压力，选择压力与Ammo酸的发生相关性

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With the help of the empirical mutation table for nucleotides in the Borrelia burgdorferi genome we have performed Monte Carlo simulation of the pure mutation pressure experienced by the genes of the genome. We have examined the divergence of the mutated genes from the ancestral ones and we have constructed MPM1 matrix (Mutation Probability Matrix) of the substitution rates between amino acids of the diverging genes. The results have been compared to mutation data matrix PAM1 PET91 representing mutation and selection data of 16130 homologous genes od different organisms. We have found that the effective survival time of amino acids in organisms follows a power law with respect to frequency of their occurrence in genes. This makes possible to find the effect of the pure mutational pressure and the selection on the amino acid composition of genes. The results are universal in the sense that the survival time of amino acids calculated from the higher order PAMκ matrices (κ > 1) follows the same power law as in the case of PAM1 matrices.

机译：借助于Borrelia Burgdorferi基因组中的核苷酸的经验突变表，我们已经进行了基因组基因所经历的纯突变压力的蒙特卡罗模拟。我们已经研究了来自祖先的突变基因的分歧，并且我们已经构成了发散基因的氨基酸之间的替代率的MPM1基质（突变概率矩阵）。结果与表示16130个同源基因的突变和选择数据不同生物的突变数据矩阵PAM1 PEAM1 PEAM1 PET91进行比较。我们发现有机体中氨基酸的有效存活时间跟随幂律相对于它们在基因中发生的频率。这使得可以找到纯突变压力和选择对基因氨基酸组成的影响。结果是普遍的意义：从高阶PAMκ矩阵（κ1）计算的氨基酸的存活时间遵循与PAM1矩阵的情况相同的电力法。

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《International conference on computational science》|2003年||共8页
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1. Natural Selection for Kinetic Stability Is a Likely Origin of Correlations between Mutational Effects on Protein Energetics and Frequencies of Amino Acid Occurrences in Sequence Alignments. [J] . Godoy Ruiz R, Ariza F, Rodriguez Larrea D, Journal of Molecular Biology . 2006,第5期

机译：动力学稳定性的自然选择是对蛋白质能量的突变影响与序列比对中氨基酸发生频率之间相关性的可能起源。
2. Modelling mutational and selection pressures on dinucleotides in eukaryotic phyla –selection against CpG and UpA in cytoplasmically expressed RNA and in RNA viruses [J] . Peter Simmonds, Wenjun Xia, J Kenneth Baillie, BMC Genomics . 2013,第1期

机译：模拟真核生物门中二核苷酸的突变和选择压力-在细胞质表达的RNA和RNA病毒中针对CpG和UpA的选择
3. Mutational Signatures Are Critical for Proper Estimation of Purifying Selection Pressures in Cancer Somatic Mutation Data When Using the dN/dS Metric [J] . Van den Eynden, Jimmy Frontiers in Genetics . 2017,第1期

机译：当使用dN / dS度量标准时，突变签名对于正确估计纯化癌症体细胞突变数据中的选择压力至关重要。
4. Correlation between Mutation Pressure, Selection Pressure, and Occurrence of Ammo Acids [C] . Aleksandra Nowicka, Pawel Mackiewicz, Malgorzata Dudkiewicz, International Conference on Computational Science - ICCA 2003 Pt.2 Jun 2-4, 2003 Melbourne, Australia and St. Petersburg, Russia . 2003

机译：突变压力，选择压力与氨酸发生率的相关性
5. High pressure protein denaturation: Description of a high pressure intermediate and effects of mutations on pressure stability [D] . Bondos, Sarah Elizabeth 1998

机译：高压蛋白质变性：高压中间体的描述以及突变对压力稳定性的影响
6. Modelling mutational and selection pressures on dinucleotides in eukaryotic phyla –selection against CpG and UpA in cytoplasmically expressed RNA and in RNA viruses [O] . Peter Simmonds, Wenjun Xia, J Kenneth Baillie, 2013

机译：模拟真核生物门中二核苷酸的突变和选择压力-在细胞质表达的RNA和RNA病毒中针对CpG和UpA的选择
7. Correlation between mutation pressure, selection pressure and occurrence of amino acids [O] . Nowicka, A., Mackiewicz, P., Dudkiewicz, M., 2003

机译：突变压力，选择压力与发生的相关性氨基酸

Correlation between Mutation Pressure, Selection Pressure, and Occurrence of Ammo Acids

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