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首页> 外文会议>International Conference on Computational Science - ICCA 2003 Pt.2 Jun 2-4, 2003 Melbourne, Australia and St. Petersburg, Russia >Correlation between Mutation Pressure, Selection Pressure, and Occurrence of Ammo Acids
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Correlation between Mutation Pressure, Selection Pressure, and Occurrence of Ammo Acids

机译：突变压力，选择压力与氨酸发生率的相关性

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摘要

With the help of the empirical mutation table for nucleotides in the Borrelia burgdorferi genome we have performed Monte Carlo simulation of the pure mutation pressure experienced by the genes of the genome. We have examined the divergence of the mutated genes from the ancestral ones and we have constructed MPM1 matrix (Mutation Probability Matrix) of the substitution rates between amino acids of the diverging genes. The results have been compared to mutation data matrix PAM1 PET91 representing mutation and selection data of 16130 homologous genes od different organisms. We have found that the effective survival time of amino acids in organisms follows a power law with respect to frequency of their occurrence in genes. This makes possible to find the effect of the pure mutational pressure and the selection on the amino acid composition of genes. The results are universal in the sense that the survival time of amino acids calculated from the higher order PAMκ matrices (κ > 1) follows the same power law as in the case of PAM1 matrices.
机译：借助于伯氏疏螺旋体基因组中核苷酸的经验突变表，我们对基因组基因经历的纯突变压力进行了蒙特卡洛模拟。我们检查了祖先突变基因的差异，并构建了差异基因氨基酸之间取代率的MPM1矩阵（突变概率矩阵）。将结果与代表不同生物体的16130个同源基因的突变和选择数据的突变数据矩阵PAM1 PET91进行了比较。我们已经发现，氨基酸在生物体中的有效存活时间关于其在基因中出现的频率遵循幂律。这使得有可能发现纯突变压力和选择对基因氨基酸组成的影响。从高阶PAMκ矩阵（κ> 1）计算得出的氨基酸的存活时间遵循与PAM1矩阵相同的幂定律，从某种意义上说，该结果具有普遍性。

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