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首页> 外文会议>Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V >Photodynamic therapy (PDT) as a biological modifier
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Photodynamic therapy (PDT) as a biological modifier

机译：光动力疗法（PDT）作为生物修饰剂

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Abstract: The capacity of photosensitizers and light to ablate cancerous tissues and unwanted neovasculature constitutes the classical application of photodynamic therapy (PDT). Cell death results from either necrotic or apoptotic processes. The use of photosensitizers and light at doses which do not cause death has been found to affect changes in certain cell populations which profoundly effect their expression of cell surface molecules and secretion of cytokines, thereby altering the functional attributes of the treated cells. Cells of the immune system and the skin may be sensitive to modulation by 'sub-lethal PDT.' Ongoing studies have been conducted to assess, at the molecular level, changes in both lymphocytes and epidermal cells (EC) caused by treatment with low levels of benzoporphyrin derivative monoacid ring A (BPD) (a photosensitizer currently in clinical trials for cancer, psoriasis, endometriosis and age-related macular degeneration) and light. Treatment of skin with BPD and light, at levels which significantly enhanced the length of murine skin allograft acceptance, have been found to down-regulate the expression of Langerhans cell (LC) surface antigen molecules $LB@major histocompatibility complex (MHC) class II and intracellular adhesion molecule (ICAM)-1$RB and the formation of some cytokines (tumor necrosis factor-alpha (TNF- $alpha@). !12
机译：摘要：光敏剂和光消融癌组织和有害的新脉管系统的能力构成了光动力疗法（PDT）的经典应用。细胞死亡是由坏死或凋亡过程导致的。已经发现以不引起死亡的剂量使用光敏剂和光会影响某些细胞群的变化，这些变化深刻地影响了它们在细胞表面分子的表达和细胞因子的分泌，从而改变了所处理细胞的功能特性。免疫系统和皮肤细胞可能对“亚致死性PDT”的调节敏感。正在进行的研究在分子水平上评估了低水平的苯并卟啉衍生物单酸环A（BPD）（目前在癌症，牛皮癣，子宫内膜异位症和与年龄有关的黄斑变性）和光。已经发现，以BPD和光治疗皮肤能够显着延长同种异体小鼠皮肤接受的时间，可以下调Langerhans细胞（LC）表面抗原分子$ LB @主要组织相容性复合体（MHC）的表达和细胞内粘附分子（ICAM）-1 $ RB以及某些细胞因子的形成（肿瘤坏死因子-α（TNF- $α@）。！12

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