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首页> 外文会议>Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE >Early detection of bronchiolitis obliterans syndrome in lung transplant recipients with chronic rejection using home spirometry
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Early detection of bronchiolitis obliterans syndrome in lung transplant recipients with chronic rejection using home spirometry

机译：使用家庭肺量计早期发现慢性排斥反应的肺移植接受者闭塞性细支气管炎综合征

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摘要

Declining pulmonary function, as measured by staging for bronchiolitis obliterans syndrome, is considered primary indication of future chronic rejection in transplanted lungs. Staging has been evaluated in a group of transplant recipients using a paperless, electronic spirometer/diary instrument for home monitoring. Eleven of 104 lung recipients were diagnosed with chronic rejection. Seven of these subjects had performed home monitoring for a minimum of 8 months at the time of this study. Clinic and home spirometry variables were used in the staging algorithm to determine the onset and rate of clinical decline related to the rejection. Using home spirometry, the onset of decline began an average of 284 days before diagnosis of chronic rejection, which was significantly earlier (p>0.05) than the decline observed with clinic pulmonary function testing. Staging changes based on home spirometry preceded diagnosis of chronic rejection in all subjects, but only occurred in 4 of 7 subjects using clinic testing. Home spirometry can provide early and consistent indication of pulmonary decline prior to chronic rejection, and should be considered as a future component of post-transplant follow-up care.
机译：通过分期检测闭塞性细支气管炎综合征，肺功能下降被认为是未来移植肺慢性排斥反应的主要指征。已使用无纸电子肺活量计/日记仪对一组移植接受者的分期进行了分期，以进行家庭监测。 104位肺接受者中有11位被诊断为慢性排斥反应。在本研究之时，这些受试者中有7名已进行了至少8个月的家庭监护。在分期算法中使用临床和家庭肺活量测定变量来确定与排斥反应相关的临床下降的发生率和发生率。使用家庭肺量计，下降的发作平均开始于诊断为慢性排斥反应之前的284天，这比在临床肺功能测试中观察到的下降显着更早（p> 0.05）。在所有受试者中，基于家庭肺活量测定的分期更改先于慢性排斥反应的诊断，但使用临床测试仅在7名受试者中有4名发生了。家庭肺活量测定可以在慢性排斥之前提供早期和一致的肺功能下降的指示，应被视为移植后随访护理的未来组成部分。

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