Effects of aldose reductase inhibitor in diabetic rats

机译：醛糖还原酶抑制剂在糖尿病大鼠中的作用

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In microcirculation, RBC deformability is one of the most important factors. In this study, the effect of aldose reductase inhibitor (ARI) on RBC deformability in diabetic rats was investigated. Seven-week-old Wistar male rats were used as diabetic models. We injected streptozotocin (STZ) (55 mg/kg) intraperitoneally to make them diabetic. Then we administered ARI orally to the STZ rats. We classified them into STZ injected diabetic group (DM) and STZ and ARI treated diabetic group (ARI). Experiments were performed three weeks after STZ treatment. The RBC deformability was measured directly from microscope images of mesentery. From this experiment, it was found that ARI didn't alter HbA1c, but improved the decreased RBC deformability in diabetes to the normal level.

机译：在微循环中，RBC的可变形性是最重要的因素之一。在这项研究中，研究了醛糖还原酶抑制剂（ARI）对糖尿病大鼠RBC变形能力的影响。七周龄的Wistar雄性大鼠被用作糖尿病模型。我们腹膜内注射链脲佐菌素（STZ）（55 mg / kg），使他们患有糖尿病。然后，我们向STZ大鼠口服ARI。我们将其分为STZ注射糖尿病组（DM）和STZ和ARI治疗的糖尿病组（ARI）。在STZ治疗后三周进行实验。直接从肠系膜的显微镜图像测量RBC的可变形性。从该实验中发现，ARI不会改变HbA1c，但可以使糖尿病患者RBC变形能力降低至正常水平。

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《Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE》|1998年|P.3098-3099|共2页
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Nagai; T.; Sekizuka; E.;
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中图分类无线电电子学、电信技术;
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1. Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial. [J] . Hotta N, Akanuma Y, Kawamori R, Diabetes care . 2006,第7期

机译：醛糖还原酶抑制剂依帕司他对糖尿病周围神经病变的长期临床效果：为期3年的多中心比较性醛糖还原酶抑制剂-糖尿病并发症试验。
2. Effects of a Novel Potent Aldose Reductase Inhibitor, GP-1447, on Aldose Reductase Activity In Vitro and on Diabetic Neuropathy and Cataract Formation in Rats [J] . Akihiro Matsuura, Kanako Fukushima, Motoyuki Yoshida, Japanese Journal of Pharmacology . 1997,第2期

机译：新型强效醛糖还原酶抑制剂GP-1447对大鼠醛糖还原酶活性的影响以及对大鼠糖尿病性神经病变和白内障形成的影响
3. Neuropathy in diabetic mice overexpressing human aldose reductase and effects of aldose reductase inhibitor. [J] . Yagihashi S, Yamagishi SI, Wada-Ri R, Brain: A journal of neurology . 2001,第Pta12期

机译：过量表达人醛糖还原酶的糖尿病小鼠的神经病变和醛糖还原酶抑制剂的作用。
4. Effects of aldose reductase inhibitor in diabetic rats [C] . Nagai T., Sekizuka E., Institute of Electric and Electronic Engineer Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 1998

机译：醛糖还原酶抑制剂在糖尿病大鼠中的影响
5. Isolation and characterization of aldose reductase inhibitors from Wrightia tinctoria R.Br. seeds [D] . Kunaparaju, Naveen 2011

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6. Effects of Long-Term Treatment with Ranirestat a Potent Aldose Reductase Inhibitor on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats [O] . Ayumi Ota, Akihiro Kakehashi, Fumihiko Toyoda, 2013

机译：Ranirestat（一种有效的醛糖还原酶抑制剂）长期治疗对自发性糖尿病大鼠的糖尿病性白内障和神经病变的影响
7. Long-Term Clinical Effects of Epalrestat, an Aldose Reductase Inhibitor, on Diabetic Peripheral Neuropathy The 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial [O] . Nigishi Hotta Md, Yasuo Akanuma Md, Ryuzo Kawamori Md, 2015

机译：依那末抑制素（一种醛糖还原酶抑制剂）对糖尿病周围神经病变的长期临床疗效3年，多中心，比较醛糖还原酶抑制剂 - 糖尿病并发症试验
8. Structural-Based Inhibitors of the Glutathione Binding Site in Aldose Reductase, Methods of Screening Therefor and Methods of Use. [R] . Srivastava, S. K., Bhatnagar, A., Ramana, K. V. 2005

机译：基于结构的醛糖还原酶中谷胱甘肽结合位点的抑制剂，筛选方法和使用方法。

Effects of aldose reductase inhibitor in diabetic rats

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