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首页> 外文会议>International symposium on controlled release of bioactive materials;Consumer and diversified products conference >Pharmacokinetic evaluation of a novel sustained release gastroretentive dosage form of riboflavin in dogs
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Pharmacokinetic evaluation of a novel sustained release gastroretentive dosage form of riboflavin in dogs

机译：新型核黄素缓释胃滞留剂型在犬体内的药代动力学评价

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摘要

Although oral administration of drugs is convenient, this mode of administration has only limited use for a variety of important drugs that are characterized by a narrow absorption window in the upper part of the small intestine. These drugs are actively absorbed by specific carriers located at the intestine surface. In this work riboflavin was utilized as a model of such drugs (Jusko and Levy 1975). Continuous administration of the drug to the duodenum can improve its bioavailability and increase hte duration of the absorption phase. Accordingly, a gastroretentive dosage form (GRDF) enabling prolonged and controlled release of the drug in the stomach would considerably contribute to optimization of therapy with these medications.
机译：尽管口服给药很方便，但是这种给药方式仅对以小肠上部的吸收窗较窄为特征的多种重要药物具有有限的用途。这些药物被位于肠表面的特定载体主动吸收。在这项工作中，核黄素被用作此类药物的模型（Jusko和Levy 1975）。连续向十二指肠给药可改善其生物利用度并增加吸收期的持续时间。因此，能够在胃中延长和控制释放药物的胃滞留剂型（GRDF）将极大地有助于优化这些药物的治疗。

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