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首页> 外文会议>International symposium on controlled release of bioactive materials >Pharmacokinetic evaluation of a novel sustained release gastroretentive dosage form of riboflavin in dogs
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Pharmacokinetic evaluation of a novel sustained release gastroretentive dosage form of riboflavin in dogs

机译：一种新型持续释放胃肠剂量的药代动力学评价犬养殖中的核酰胺

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摘要

Although oral administration of drugs is convenient, this mode of administration has only limited use for a variety of important drugs that are characterized by a narrow absorption window in the upper part of the small intestine. These drugs are actively absorbed by specific carriers located at the intestine surface. In this work riboflavin was utilized as a model of such drugs (Jusko and Levy 1975). Continuous administration of the drug to the duodenum can improve its bioavailability and increase hte duration of the absorption phase. Accordingly, a gastroretentive dosage form (GRDF) enabling prolonged and controlled release of the drug in the stomach would considerably contribute to optimization of therapy with these medications.
机译：虽然口服药物施用是方便的，但这种给药方式仅适用于各种重要的药物，其特征在于小肠的上部窄吸收窗。这些药物被位于肠表面的特定载体积极吸收。在这项工作中，核黄素被用作这种药物的模型（Jusko和1975年）。将药物连续给十二指肠施用可以改善其生物利用度，增加吸收阶段的HTE持续时间。因此，在胃中延长和控制药物的胃内剂量形式（GRDF）可延长和控制释放的释放会对这些药物的治疗进行贡献。

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