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首页> 外文会议>International symposium on controlled release of bioactive materials;Consumer and diversified products conference >Powdered polymeric nanoparticulate system to improve pulmonary delivery of calcitonin with dry powder inhalation
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Powdered polymeric nanoparticulate system to improve pulmonary delivery of calcitonin with dry powder inhalation

机译：粉末状聚合物纳米颗粒系统可通过干粉吸入改善降钙素的肺部递送

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It was found in our previous paper (1,2) that the aqueous dispersions of DL-lactide/glycolide copolymer (PLGA) nanospheres with peptide administered pulmonaryly to guinea pig with a nebulizer improved significantly and prolonged extensively the biological action. In the present study, powdered PLGA nanocapsules and powdered matrices of hydroxypropylmethylcellulose phthalate (HPMCP) nanospheres with calcitonin were developed to improve systemic delivery of the peptide with dry powder inhalation as well as to improve compliance by reducing inhalation time with the nebulizer (e.g. 20min). To improve inhalation efficiency, the micromeritic properties of powdered nanoparticulate system were specifically designed so as to decrease their aerodynamic diameters by increasing the dynamic shape factor and/or porosity.
机译：在我们以前的论文（1,2）中发现，向带有雾化器的豚鼠肺部给药的DL-丙交酯/乙交酯共聚物（PLGA）纳米球的水分散体具有明显的改善作用，并广泛延长了其生物学作用。在本研究中，开发了粉状PLGA纳米胶囊和羟丙基甲基纤维素邻苯二甲酸酯（HPMCP）纳米球与降钙素的粉状基质，以通过干粉吸入改善肽的全身递送，并通过减少与雾化器的吸入时间（例如20分钟）来提高依从性。为了提高吸入效率，专门设计了粉状纳米颗粒系统的微球团性质，以便通过增加动态形状因数和/或孔隙率来减小其空气动力学直径。

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