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首页> 外文会议>International symposium on controlled release of bioactive materials >Powdered polymeric nanoparticulate system to improve pulmonary delivery of calcitonin with dry powder inhalation
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Powdered polymeric nanoparticulate system to improve pulmonary delivery of calcitonin with dry powder inhalation

机译：粉末状聚合物纳米颗粒系统改善降钙素肺部递送干粉吸入

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It was found in our previous paper (1,2) that the aqueous dispersions of DL-lactide/glycolide copolymer (PLGA) nanospheres with peptide administered pulmonaryly to guinea pig with a nebulizer improved significantly and prolonged extensively the biological action. In the present study, powdered PLGA nanocapsules and powdered matrices of hydroxypropylmethylcellulose phthalate (HPMCP) nanospheres with calcitonin were developed to improve systemic delivery of the peptide with dry powder inhalation as well as to improve compliance by reducing inhalation time with the nebulizer (e.g. 20min). To improve inhalation efficiency, the micromeritic properties of powdered nanoparticulate system were specifically designed so as to decrease their aerodynamic diameters by increasing the dynamic shape factor and/or porosity.
机译：它在我们之前的纸上（1,2）中发现，DL-丙交酯/乙酰胺共聚物（PLGA）纳米球的水分散体与肽给豚鼠施用的肽与雾化器显着提高，并延长了生物学作用。在本研究中，开发了羟丙基甲基纤维素邻苯二甲酸盐（HPMCP）纳米球的粉末PLGA纳米膜和粉末状基质，以改善肽的全身递送干粉吸入，以及通过减少与雾化器（例如20min）减少吸入时间来改善顺应性。为了提高吸入效率，特别设计粉末纳米颗粒系统的微立性能，以通过增加动态形状因子和/或孔隙率来降低它们的空气动力学直径。

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