Presents a new approach to high-density microelectrode arrays for spatially and temporally resolved images of in-vitro neuronal network electrophysiological activity. Based on active pixel sensor technology (APS), the first chip design consists of an array of 64 /spl times/ 64 (4096) pixels on an active area of 2.56 /spl times/ 2.56 mm/sup 2/. Each pixel has a dimension of 40 /spl times/ 40 /spl mu/m/sup 2/ integrating a gold microelectrode of 20 /spl times/ 20 /spl mu/m/sup 2/. An in-pixel differential amplifier locally amplifies the extracellular potential, minimising the electrode-measuring circuit distance. The integrated circuit has a programmable gain and filtering for noise-speed trade-off. The network activity image is obtained by addressing the desired pixels at high sampling frequency and sequentially reading the chip output.
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机译：为高密度微电极阵列提出了一种新方法，用于体外神经元网络电生理活动的时空分辨图像。基于有源像素传感器技术（APS），第一个芯片设计由2.5 / spl次/2.56 mm / sup 2 /的有效区域上的64个/ spl次/ 64（4096）个像素组成。每个像素的尺寸为40 / spl倍/ 40 / spl mu / m / sup 2 /集成了20 / spl倍/ 20 / spl mu / m / sup 2 /的金微电极。像素内差分放大器局部放大细胞外电位，从而最大程度地减少了电极测量电路的距离。集成电路具有可编程增益和滤波功能，可在噪声速度与速度之间进行权衡。通过以高采样频率寻址所需像素并顺序读取芯片输出，可以获得网络活动图像。
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