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Probing the Origins and Applications of Atypical Capacitive Cell Phenomena in Microfluidic Impedance Sensors

机译:探测微流体阻抗传感器中非典型电容细胞现象的起源和应用

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This paper investigates the origins of an uncharacteristic capacitive phenomenon in cells that is highly frequency dependent and has remained unreported until now. This behavior was observed to be consistent in >10000 individual red blood cells probed using a microfluidic impedance sensor integrated with coplanar microelectrode structures and also repeatable across different devices. To better understand the reasons for this phenomenon, the system was extensively modelled using COMSOL Multiphysics and in our findings, we report a model that greatly agrees with our experimental observations. We also describe preliminary efforts in using this novel capacitive phenomenon to overcome long-standing limitations of traditional microfluidic devices in accurate cell position sensing and obtaining vital electrical parameters of cells.
机译:本文研究了高频率依赖性的细胞中不可结构的电容现象的起源,直到现在。观察到这种行为在使用与共面微电极结构中集成的微流体阻抗传感器探测的> 10000个单独的红细胞中,并且还可以在不同的装置上重复。为了更好地了解这种现象的原因,系统广泛建模使用Comsol Multiphysics和在我们的研究结果中,我们报告了一个大大同意我们的实验观察的模型。我们还描述了使用这种新型电容现象来克服传统微流体装置在准确的细胞位置感测和获得细胞的重要电气参数的长期局限性的初步努力。

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