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Thermal measurement of cerebrospinal fluid flow rate in hydrocephalus shunt

机译：脑脊液中脑脊液流速的热量测量

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摘要

This paper presents a novel mechanism for convenient in vitro measurement of cerebrospinal fluid flow rate in hydrocephalus shunts. Thermal time of flight method has been employed in the measurements conducted on a modified shunt system covered with artificial skin. The shunt tube is proposed to include bio-compatible materials such as titanium for better thermal responses. To facilitate clinical measurements by neurosurgeons, a dry, semiconductor thermoelectric cooling device has been designed to initiate the thermal transfer while maintaining a safe operating temperature and clean thermal excitation. Velocity thus flow rate of the cerebrospinal fluid has been derived by decoupling the thermal transfer in the measured differential time at two measurement spots of the titanium elements. Device design was based on comprehensive system simulation using finite element analyses on the fluidic and thermal behaviors of the shunt system. Microcontroller and proper control schemes have been used for desired thermal excitation and temperature registrations. The mechanism has been validated in measurements conducted on a laboratory setup consisting of the modified shunt, covered by commercial synthetic human skins in an environment similar to human physiology. The measurement results have demonstrated good agreements with the simulation results in the clinically practical flow rates ranging from 0.5 mm/sec to 1.0 mm/sec.
机译：本文提出了一种新的脑脊液分流脑脊液流速体外测量的新机制。在用人造皮肤覆盖的改进的分流系统上进行的测量中采用了飞行方法的热时间。提出分流管以包括生物相容的材料，例如钛以获得更好的热反应。为了促进神经外科和神经外部的临床测量，设计用于在保持安全操作温度和清洁热激励的同时启动热转印和清洁的热励磁。因此，通过在钛元件的两个测量点处在测量的差分时间中解耦热传递来导出脑脊液的流速。设备设计基于使用有限元分析分流系统的流体和热行为的综合系统仿真。微控制器和适当的控制方案已用于所需的热激励和温度注册。该机制已在对实验室设置的测量中验证，该测量由改性分流器组成，由类似于人体生理学的环境中的商业合成人体皮。测量结果表明，临床实际流速范围为0.5毫米/秒至1.0mm /秒的临床实际流速的良好协议。

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