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首页> 外文会议>World congress on medical physics and biomedical engineering >Nanoscaled San-Huang-Xie-Xin-Tang Suppresses Liver Hepatic Stellate Cell Activation and Fibrosis by TGF-β_1
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Nanoscaled San-Huang-Xie-Xin-Tang Suppresses Liver Hepatic Stellate Cell Activation and Fibrosis by TGF-β_1

机译：纳米级三 - 黄谢新唐通过TGF-β_1抑制肝肝星状细胞活化和纤维化

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Nanotechnology is one of the core technologies in the 21st century. It has potentials for applying to medicine, pharmacy, and Chinese herbal medicine. The quality, efficiency, and safety of nanoscaled Chinese herbs are different from traditional drug form. In this study, the hepatoprotective Chinese herb "San-Huang-Xie-Xin-Tang (SHXXT)" was investigated. Hepatic stellate cells (HSCs) which played a key role on liver fibrosis were activated by transforming growth factor-beta l(TGF-Pi) and then exposed to the extracts of air-dried SHXXT, micro-powdered SHXXT, and nanoscaled SHXXT, respectively. The results showed that MMP-2, TIMP-1, and Bcl-2 mRNA expressions from HSCs were reduced by treating with the extract of nanoscaled SHXXT. However, the expression of Bax and Fas/FasL mRNA were induced. These results suggested that the extract of nanoscaled SHXXT could not only inhibited significantly the progression of hepatic fibrosis induced by TGF-β_1, but inhibited the proliferation of activated hepatic stellate cells.
机译：纳米技术是21世纪的核心技术之一。它有申请医学，药房和中草药的潜力。纳米中草药的质量，效率和安全性与传统药物形式不同。在这项研究中，调查了肝保护性中草药“San-Huang-xie-xin-tang（Shxxt）”。通过转化生长因子-β1（TGF-PI）来激活在肝纤维化中发挥关键作用的肝星状细胞（HSCs），然后分别暴露于风干SHXXT，微粉SHXXT和纳米级SHXXT的提取物中。结果表明，通过用纳米级SHXXT的提取物处理来自HSCs的MMP-2，TIMP-1和BCL-2 mRNA表达。但是，诱导了Bax和Fas / FasL mRNA的表达。这些结果表明，纳米级SHXXT的提取物不仅可以显着抑制TGF-β_1诱导的肝纤维化的进展，但抑制了活化的肝星状细胞的增殖。

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