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首页> 外文会议>IEEE International Ultrasonics Symposium >Carotid artery non invasive elastography (NIVE) to detect early changes of cardiovascular diseases in overweight and obese children
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Carotid artery non invasive elastography (NIVE) to detect early changes of cardiovascular diseases in overweight and obese children

机译：颈动脉无侵入性弹性术（尼斯）检测超重和肥胖儿童心血管疾病的早期变化

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Increased arterial stiffness is one of the first signs of atherosclerosis. The objective of this study was to use non-invasive elastography (NIVE) to detect early changes in vascular biomechanics associated with obesity in children. The NIVE algorithm also measured the intimamedia thickness (IMT) for comparison. NIVE was applied in 120 children, 60 with elevated body mass index (BMI) (≥ 85 th percentile for age and sex) and 60 non-overweight (BMI <; 85 th percentile). Participants were randomly selected from a longitudinal cohort, evaluating consequences of obesity in healthy children with one obese parent. The carotid wall was automatically segmented and elastograms were computed to measure the cumulated axial strain (CAS), cumulated axial translation (CAT), and maximal shear strain (Max |SSE|); IMT was also computed from segmented contours. Elastogram features were compared between groups with multivariate analyses to control for age, sex, Tanner stage, blood pressure, and low-density lipoprotein cholesterol (LDL). After Bonferroni correction, CAT was significantly higher in the elevated BMI group (0.68 ± 0.24 mm vs. 0.52 ± 0.18 mm), p <; 0.001. CAS/CAT was significantly lower in the elevated BMI group (9.54 ± 4.8 %/mm vs. 13.34 ± 6.46 %/mm), p = 0.001; the lower CAS/CAT ratio suggests stiffer arteries with less deformation for a similar translation. Before Bonferroni correction, IMT was significantly higher in the elevated BMI group (0.36 ± 0.05 mm vs. 0.32 ± 0.05 mm), p = 0.013. IMT statistical difference was no longer significant after Bonferroni correction. After Bonferroni correction, NIVE detected differences in CAT and CAS/CAT biomarkers in elevated BMI children, whereas IMT failed to show a difference. NIVE is a promising technique to monitor radiological biomarkers of subclinical atherosclerosis in the pediatric population.
机译：增加的动脉僵硬是动脉粥样硬化的第一个迹象之一。本研究的目的是使用非侵入性弹性摄影（Nive）来检测与儿童肥胖症相关的血管生物力学的早期变化。 Nive算法还测量了用于比较的Intimamia厚度（IMT）。 Nive应用于120名儿童，60名儿童，升高的体重指数（BMI）（年龄和性别≥85百分位数）和60个非超重（BMI <; 85百分位数）。参与者从纵向队列中随机选择，评估一个肥胖父母的健康儿童的肥胖后果。颈动脉壁自动分段，计算弹性图以测量累积的轴向应变（CAS），累积轴向翻译（CAT）和最大剪切菌株（MAX | SSE |）; IMT也从分段轮廓计算。在具有多变量分析的组之间进行弹性图特征，以控制年龄，性别，坦纳阶段，血压和低密度脂蛋白胆固醇（LDL）。在Bonferroni校正之后，肝脏升高的BMI组（0.68±0.24 mm，0.52±0.18mm），P <; 0.001。升高的BMI组Cas /猫显着较低（9.54±4.8％/ mm与13.34±6.46％/ mm），p = 0.001;下CAS /猫比表明，对于类似翻译的变形较小，方案令人越来越多。在Bonferroni校正之前，IMT在升高的BMI组中显着高（0.36±0.05 mm与0.32±0.05 mm），P = 0.013。在Bonferroni校正后，IMT统计学差异不再重要。在Bonferroni校正之后，Nive检测到BMI儿童升高的CAT和CAS / CAT生物标志物的差异，而IMT无法显示出差异。 Nive是一种有希望监测儿科人群亚临床动脉粥样硬化的放射生物标志物的技术。

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