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Inverse estimation of ventricular Purkinje tree pathways from sequences of depolarization

机译：从去极化序列反推心室浦肯野树路径

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摘要

The electrical activation of the heart is a complex process that is essential for the understanding and treatment of several cardiac dysfunctions, such as ventricular tachycardia. Patient-specific local activation times (LAT) are usually obtained using electro-anatomical maps, however unveiling the underlying fast pathways formed by the Purkinje network remains a complex problem. We present a method based on differential geometry to estimate from a set of endocardium LATs, the locations on the endocardium with a potential number of Purkinje myocardial junctions, and the corresponding Purkinje branching structure. We evaluate our method on biophysical simulations using several Purkinje configurations. LAT errors of estimated Purkinje trees are in the order of 6 ms.

机译：心脏的电激活是一个复杂的过程，对于理解和治疗几种心脏功能障碍（例如心室性心动过速）至关重要。通常使用电解剖图获得患者特定的局部激活时间（LAT），但是揭开由Purkinje网络形成的基本快速途径仍然是一个复杂的问题。我们提出了一种基于微分几何的方法，可从一组心内膜LAT，心内膜上具有潜在数量的Purkinje心肌结的位置以及相应的Purkinje分支结构进行估计。我们使用几种浦肯野配置对我们的方法进行生物物理模拟评估。估计的Purkinje树的LAT误差约为6 ms。

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《Computing in Cardiology Conference》|2014年|677-680|共4页
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Cardenes Ruben; Sebastian Rafael; Berruezo Antonio; Camara Oscar;
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bioelectric potentials; blood vessels; cardiology; differential geometry; medical disorders; Purkinje branching structure; Purkinje configurations; Purkinje myocardial junctions; Purkinje network; cardiac dysfunction treatment; depolarization sequences; electroanatomical maps; endocardium LATs; heart electrical activation; local activation times; ventricular tachycardia; Abstracts; Biological system modeling; Computed tomography; Equations; Mathematical model; Vents;

机译：生物电势;血管;心脏病;微分几何;医学障碍; Purkinje分支结构; Purkinje构型; Purkinje心肌交界处; Purkinje网络;心脏功能障碍治疗;去极化序列;电解剖图;心内膜LATs;心脏电激活;局部激活时间;心室心动过速;摘要;生物学系统建模;计算机断层扫描;方程;数学模型;通风孔;

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1. Electrophysiological characterization of BRL-32872 in canine Purkinje fiber and ventricular muscle. Effect on early after-depolarizations and repolarization dispersion. [J] . Faivre JF, Forest MC, Gout B, European Journal of Pharmacology: An International Journal . 1999,第2期

机译：犬浦肯野纤维和心室肌中BRL-32872的电生理特性。对早期后去极化和复极化分散的影响。
2. Purkinje and ventricular contributions to endocardial activation sequence in perfused rabbit right ventricle. [J] . Cates AW, Smith WM, Ideker RE, American Journal of Physiology . 2001,第2期

机译：Purkinje和心室对灌注兔右心室心内膜激活序列的贡献。
3. Ventricular premature depolarization QRS duration as a new marker of risk for the development of ventricular premature depolarization-induced cardiomyopathy [J] . CarballeiraPolL., DeyellM.W., FrankelD.S., Heart rhythm: the official journal of the Heart Rhythm Society . 2014,第2期

机译：心室过早去极化QRS持续时间是发生室性过早去极化所致心肌病的新危险标志
4. Inverse estimation of ventricular Purkinje tree pathways from sequences of depolarization [C] . Cardenes Ruben, Sebastian Rafael, Berruezo Antonio, Computing in Cardiology Conference . 2014

机译：从去极化序列逆估计心室紫癜树途径
5. Anatomically Realistic Structural Modeling of the Cardiac Purkinje Network A Basis for Studying Contributions of the Conduction System to Ventricular Arrhythmias. [D] . Liu, Benjamin. 2014

机译：心脏Purkinje网络的解剖学逼真的结构模型，是研究传导系统对室性心律失常贡献的基础。
6. A case of ventricular fibrillation triggered by ventricular premature depolarizations exiting from different sites of the Purkinje network [O] . Stavros E. Mountantonakis, Haisam Ismail, David Lin 2015

机译：从Purkinje网络的不同部位流出的室性过早去极化引发的室颤
7. Purkinje and ventricular activation sequences of canine papillary muscle. Effects of quinidine and calcium on the Purkinje-ventricular conduction delay. [O] . R D Veenstra, R W Joyner, D A Rawling 1984

机译：犬磷脂肌的休金胚和心室激活序列。奎尼丁与钙对浦京腹心室传导延迟的影响。
8. How the Purkinje System Determines the Ventricular Activation Sequence. [R] . Joyner, R. W. 2001

机译：浦肯野系统如何确定心室激动序列。

Inverse estimation of ventricular Purkinje tree pathways from sequences of depolarization

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