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Evaluation of a Novel Wafer-Scale CMOS APS X-Ray Detector for Use in Mammography

机译:用于乳房X线照相术用新型晶片级CMOS APS X射线检测器的评估

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The most important factors that affect the image quality are contrast, spatial resolution and noise. These factors and their relationship are quantitatively described by the Contrast-to-Noise Ratio (CNR), Signal-to-Noise Ratio (SNR), Modulation Transfer Function (MTF), Noise Power Spectrum (NPS) and Detective Quantum Efficiency (DQE) parameters. The combination of SNR, MTF and NPS determines the DQE, which represents the ability to visualize object details of a certain size and contrast at a given dose. In this study the performance of a novel large area Complementary Metal-Oxide-Semiconductor (CMOS) Active Pixel Sensor (APS) X-ray detector, called DynAMITe (Dynamic range Adjustable for Medical Imaging Technology), was investigated and compared to other three digital mammography systems (namely a) Large Area Sensor (LAS), b) Hamamatsu C9732DK, and c) Anrad SMAM), in terms of physical characteristics and evaluation of the image quality. DynAMITe detector consists of two geometrically superimposed grids: a) 2560 x 2624 pixels at 50 μm pitch, named Sub-Pixels (SP camera) and b) 1280 x 1312 pixels at 100 μm pitch, named Pixels (P camera). The X-ray performance evaluation of DynAMITe SP detector demonstrated high DQE results (0.58 to 0.64 at 0.5 lp/mm). Image simulation based on the X-ray performance of the detectors was used to predict and compare the mammographic image quality using ideal software phantoms: a) one representing two three dimensional (3-D) breasts of various thickness and glandularity to estimate the CNR between simulated microcalcifications and the background, and b) the CDMAM 3.4 test tool for a contrast-detail analysis of small thickness and low contrast objects. The results show that DynAMITe SP detector results in high CNR and contrast-detail performance.
机译:影响图像质量的最重要因素是对比度,空间分辨率和噪音。通过对比度 - 噪声比(CNR),信噪比(SNR),调制传递函数(MTF),噪声功率谱(NPS)和侦探量子效率(DQE)来定量描述这些因素及其关系。参数。 SNR,MTF和NPS的组合决定了DQE,其表示能够在给定剂量以特定尺寸和对比度的对象细节可视化。在该研究中,研究了新颖的大面积互补金属 - 氧化物 - 半导体(CMOS)有源像素传感器(APS)X射线检测器的性能,称为炸药(用于医学成像技术的动态范围),并与其他三种数字相比乳房X线摄影系统(即A)大面积传感器(LAS),B)Hamamatsu C9732DK,和C)Anrad SMAM),就物理特性和图像质量评估而言。炸药检测器由两个几何叠加网格组成:a)在50μm间距,命名子像素(sp摄像机)和b),命名为100μm间距,命名像素(p摄像机)。炸药SP检测器的X射线性能评估显示出高DQ​​E结果(0.58至0.64,0.5磅/mm)。基于探测器的X射线性能的图像仿真用于预测和比较使用理想的软件幻影的乳房X线图图像质量:a)一种代表各种厚度和腺体的三维(3-d)乳房,以估计之间的CNR模拟微钙化和背景,B)CDMAM 3.4测试工具,用于对比较和低对比度物体的对比度分析。结果表明,炸药SP检测器导致高CNR和对比度性能。

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