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首页> 外文会议>Conference on Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics >Quantitative, spectrally-resolved intraoperative fluorescence imaging for neurosurgical guidance in brain tumor surgery: pre-clinical and clinical results
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Quantitative, spectrally-resolved intraoperative fluorescence imaging for neurosurgical guidance in brain tumor surgery: pre-clinical and clinical results

机译：定量，光谱分辨术中荧光成像在脑肿瘤外科手术中的神经外科指导：临床前和临床结果

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摘要

Fluorescence-guidance is a useful adjunct to maximize brain tumor resection but current commercial systems are limited by subjective assessment of fluorescence, low sensitivity and non-spectrally-resolved detection. We present a quantitative, spectrally-resolved system integrated onto a commercial neurosurgical microscope that performs spectrally-resolved detection and corrects for effects of tissue optical absorption and scattering on the detected fluorescence signal to image the true fluorophore concentration. Pre-clinical studies in rodent glioma models using multiple fluorophores (PpⅨ, fluorescein) and clinical studies demonstrate improved residual tumor tissue detection. This quantitative, spectrally-resolved technique opens the door to simultaneous image-guided surgery of multiple fluorophores in the visible and near infrared.
机译：荧光引导是使脑肿瘤切除最大化的有用辅助手段，但是当前的商业系统受到荧光的主观评估，低灵敏度和非光谱分辨检测的限制。我们提出了一种集成到商业神经外科显微镜上的定量，光谱分辨系统，该系统执行光谱分辨检测并校正组织光吸收和散射对检测到的荧光信号的影响，以对真实的荧光团浓度进行成像。使用多种荧光团（PpⅨ，荧光素）的啮齿动物神经胶质瘤模型的临床前研究和临床研究表明，残留肿瘤组织的检测得到了改善。这种定量的，光谱分辨的技术为在可见光和近红外光中同时进行多个荧光团的图像引导手术打开了大门。

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