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A new technique for layout based functional testing of modules in Digital Microfluidic Biochips

机译：基于布局的数字微流控生物芯片模块功能测试新技术

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Microfluidic based biochips as a composite microsystem offers an alternative platform for conventional laboratory procedures. In recent years a new generation of such lab on chip devices namely Digital Microfluidic Biochip is emerged as a suitable application for concurrent and scalable integration of multiple bioassay protocols. Dependability and accuracy are major issues for safety critical applications of DMFBs specifically in the areas of clinical diagnostics and other biochemical applications. Functional testing is targeted towards assessment of reliability of basic microfluidic operations namely merging, mixing, splitting and incubation. In this paper we proposed a layout specific functional testing method that detects faults in a prespecified group of cells already placed within a 2D array for execution of a given bioassay protocol. The objective is to minimize the test completion time, optimize test resources and customize the test for prespecified cluster of cells to be utilized as modules dedicated for microfluidic operations. The simulation is carried out on testbenches of Benchmark suite III and the results are found to be encouraging.
机译：基于微流体的生物芯片作为复合微系统为常规实验室程序提供了替代平台。近年来，新一代的此类芯片实验室设备，即数字微流控生物芯片，已经出现在多种生物测定方案的同时和可扩展集成中，是一种合适的应用。可靠性和准确性是DMFB安全关键应用的主要问题，特别是在临床诊断和其他生化应用领域。功能测试旨在评估基本微流操作（即合并，混合，分离和孵育）的可靠性。在本文中，我们提出了一种布局特定的功能测试方法，该方法可以检测已经放置在2D阵列中以执行给定生物测定规程的一组预定细胞中的故障。目的是最大程度地减少测试完成时间，优化测试资源并针对预先指定的细胞簇定制测试，以将其用作专用于微流体操作的模块。在Benchmark套件III的测试平台上进行了仿真，结果令人鼓舞。

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