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Fabrication of Custom PCL Scaffold for Nasal Septal Perforation Repair

机译：定制PCL支架进行鼻中隔穿孔修复的制作

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Nasal septal perforations (NSPs) are relatively common. They can be problematic for both patients and head and neck reconstructive surgeons who attempt to repair them. Often, this repair is made using an interpositional graft sandwiched between bilateral mucoperichondrial advancement flaps. The ideal graft is nasal septal cartilage. However, many patients with NSP lack sufficient septal cartilage to harvest. Harvesting other sources of autologous cartilage grafts, such as auricular cartilage, adds morbidity to the surgical case and results in a graft that lacks the ideal qualities required to repair the nasal septum. Tissue engineering has allowed for new reconstructive protocols to be developed. Currently, the authors are unaware of any new literature that looks to improve repair of NSP using custom tissue-engineered cartilage grafts. The first step of this process involves developing a protocol to print the graft from a patient's pre-operative CT.In this study, CT scans were converted into STereoLithography (STL) file format. The subsequent STL files were transformed into 3D printable G-Code using the Slic3r software. This allowed us to customize the parameters of our print and we were able to choose a layer thickness of 0.1mm. A desktop 3D bioprinter (BioBot 1) was then used to construct the scaffold.This method resulted in the production of a PCL scaffold that precisely matched the patient's nasal septal defect, in both size and shape. This serves as the first step in our goal to create patient-specific tissue engineered nasal septal cartilage grafts for NSP repair.
机译：鼻中隔穿孔（NSP）比较常见。对于试图修复它们的患者以及头部和颈部重建外科医师而言，它们可能都是成问题的。通常，这种修复是使用夹在双侧粘膜软骨膜前移瓣之间的介入移植物进行的。理想的移植物是鼻中隔软骨。但是，许多NSP患者缺乏足够的间隔软骨以进行收获。收获其他来源的自体软骨移植物（例如耳软骨）会增加手术病例的发病率，并导致移植物缺乏修复鼻中隔所需的理想质量。组织工程学已经允许开发新的重建方案。目前，作者们还没有发现任何新的文献希望通过定制的组织工程软骨移植来改善NSP的修复。此过程的第一步涉及制定协议，以从患者术前的CT上打印出移植物。在本研究中，CT扫描被转换为STereoLithography（STL）文件格式。使用Slic3r软件将后续的STL文件转换为3D可打印的G代码。这使我们能够自定义打印参数，并且我们能够选择0.1mm的层厚度。然后使用台式3D生物打印机（BioBot 1）来构建支架，该方法导致了PCL支架的生产，该支架在尺寸和形状上均与患者的鼻中隔缺损精确匹配。这是我们创建针对NSP修复的患者特定组织工程鼻中隔软骨移植物的目标的第一步。

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