• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Physiology, Function, and Structure from Medical Images >Correlations between DTI and FLAIR Images Reveal the Relationships of Microscopic and Macroscopic White Matter Degeneration in Elderly Subjects
【24h】

Correlations between DTI and FLAIR Images Reveal the Relationships of Microscopic and Macroscopic White Matter Degeneration in Elderly Subjects

机译：DTI和FLAIR图像之间的相关性揭示了老年人中微观和宏观白色物质变性的关系

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Fluid attenuated inversion recovery (FLAIR) detects the T2 prolongation in whiter matter lesions (WML) measured on a macroscopic scale, whereas diffusion tensor imaging (DTI) more specifically detects the white matter (WM) integrity alterations as measured by water diffusion on a microscopic scale. Both techniques have been widely used to evaluate WM changes associated with aging, dementia and cerebral vascular disease, however, the relationship between white matter lesions (FLAIR) and changes of DTI remains largely unknown. We addressed this issue using a voxel based correlation analysis between DTI and FLAIR images acquired from 33 elderly subjects at 4T. The WML volume and intensity were correlated the fraction anisotropy (FA) or mean diffusivity (MD) across all the subjects on a voxelwise basis. Our results revealed that significant DTI-WML correlations occur at regions overlapping the major WML distributions with moderate intensity, and that no significant correlations were detected in periventricular regions where the FLAIR intensities are particularly high. We investigated WM degeneration as a continuum from normal WM to cerebrospinal fluid (CSF) using a two-compartment WM model. The simulation results indicated that the FLAIR intensity of WML reaches a maximum when the lesion severity is around 0.7, which is the same point where correlations between DTI and WML disappear. Based on these findings, WM degeneration in elderly subjects may be better characterized by using regional DTI-WML correlations in different stages of WM degeneration. DTI and FLAIR, taken together improve specificity for characterization of WM degeneration than each measure alone.
机译：液体衰减反转恢复（FLAIR）在宏观尺度上检测白质病变（WML）中的T2延长，而弥散张量成像（DTI）更具体地检测通过在显微镜下通过水扩散测量的白质（WM）完整性变化。规模。两种技术已被广泛用于评估与衰老，痴呆和脑血管疾病相关的WM变化，但是，白质病变（FLAIR）与DTI变化之间的关系仍然未知。我们使用基于体素的相关分析解决了这个问题，该分析在4T时从33位老年受试者获取的DTI和FLAIR图像之间进行。 WML的体积和强度以体素为基础与所有受试者的分数各向异性（FA）或平均扩散率（MD）相关。我们的结果表明，在中等强度下，与主要WML分布重叠的区域出现了显着的DTI-WML相关性，而在FLAIR强度特别高的心室周围区域中未检测到显着相关性。我们使用两室WM模型研究了从正常WM到脑脊液（CSF）的连续性的WM变性。仿真结果表明，当病灶严重度约为0.7时，WML的FLAIR强度达到最大值，这是DTI和WML之间相关性消失的同一点。基于这些发现，通过在WM变性的不同阶段使用区域DTI-WML相关性，可以更好地表征老年受试者的WM变性。 DTI和FLAIR一起使用，比单独使用每种方法都能提高表征WM变性的特异性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号