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Simultaneous Contrast Ultrasound And DCE MRI For Improved Breast Tumour Characterization: Demonstration Of Technical Feasibility

机译:同时对比度超声和DCE MRI改善乳腺肿瘤特性:技术可行性的示范

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Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) shows promise for characterizing breast tumours and monitoring their response to therapies. Unfortunately, it suffers from the limitation that the measured signal arises from both within and outside blood vessels, and the images cannot be acquired fast enough to accurately characterize tumours. Contrast ultrasound signals arise only from blood and can be acquired with high temporal resolution, addressing two major weaknesses of DCE-MRI. The technical feasibility of combining contrast ultrasound imaging with DCE-MRI for simultaneous measurements of contrast agent dynamics was explored in this study. Pulse-inversion B-scan ultrasound imaging was performed in a closed-bore clinical MR imager using a nonmagnetic linear positioning system, and by placing the pre-amps and isolation circuits at the bore of the magnet. Initial experiments in a rabbit kidney model demonstrate the feasibility of performing simultaneous contrast imaging with both modalities.
机译:动态对比度增强的磁共振成像(DCE-MRI)显示了表征乳腺肿瘤并监测其对疗法的反应的承诺。遗憾的是,它受到限制,测量信号由血管内部和外部血管内部产生,并且图像不能足够快地获取以准确地表征肿瘤。对比度超声信号仅由血液产生,并且可以以高时间分辨率获取,解决DCE-MRI的两个主要弱点。本研究探讨了与DCE-MRI与DCE-MRI相结合的技术可行性,在本研究中探讨了对造影剂动态的同时测量。使用非磁性线性定位系统在闭孔临床MR图像中进行脉冲反转B扫描超声成像,并通过将预先放大器和隔离电路放置在磁体的孔中。兔肾模型中的初始实验证明了与两种方式进行同时对比度成像的可行性。

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