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The spp biotech module 1: proteins for amedical applications a multidisciplinary effort for the development of a recombinant anti-RhD antibody preparation for the prevention of Hemolytic Disease of the Newborn

机译：SPP Biotech模块1：用于AMEDICY应用的蛋白质，用于开发重组抗RHD抗体制剂的多学科努力，用于预防新生儿的溶血性疾病

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Hemolytic Disease of the Newborn (HDN) can be a life threatening condition in Rh D positive babies born from Rh D negative mothers. For several decades, prophylactic treatment with immunoglobulins derived from human blood plasma from immunized donors has been available. Because of concerns for donor safety and limited supply of raw material, alternatives for production of specific immunoglobulins were investigated. Since 1994 ZLB has, in collaboration with a group at the University Hospital in Bern, started to develop recombinant anti-D antibodies. In 1997, a multidisciplinary team with expertise ranging from molecular biology to biochemical engineering for large scale operations was constituted, co-funded by the Swiss National Science Foundation and ZLB, as the industrial partner. The aims of this team are to establish the prophylactic principle and the manufacturing process for anti-D therapy based on recombinant antibody preparations produced from Chinese hamster ovary (CHI) cells.

机译：新生儿（HDN）的溶血性疾病可以是RH D消极母亲出生的RH D阳性婴儿的危及危及疾病状态。几十年来，已有来自免疫供体的来自人血浆的免疫球蛋白的预防性处理。由于施主安全和原料供应有限的担忧，研究了特异性免疫球蛋白的生产替代品。自1994年以来，ZLB与伯尔尼大学医院的一组合作开始开发重组抗D抗体。 1997年，一个具有专业知识的多学科团队，从分子生物学到大规模行动的生化工程，由瑞士国家科学基金会和ZLB为工业伴侣共同资助。该团队的目的是建立基于来自中国仓鼠卵巢（CHI）细胞生产的重组抗体制剂的预防性原理和抗D治疗的制造方法。

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《Annual Meeting of the European Society of Animal Cell Technology》|1999年||共4页
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H.AMSTUTZ; S.MIESCHER; R.MOUDRY;
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中图分类 Q952-532;
关键词
proteins for medical; applications; recombinant anti-rhd antibody; Hemolytic Disease of the Newborn (HDN);

机译：医疗蛋白质;应用;重组抗RHD抗体;新生儿（HDN）的溶血性疾病;

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机译：使用重组蛋白制剂开发特异于白斑综合症病毒（WSSV）VP19包膜蛋白的多克隆抗体
3. Development and evaluation of an enzyme-linked immunosorbent assay based on a recombinant spaa protein (rSpaA415) for detection of anti-Erysipelothrix spp. IgG antibodies in pigs. [J] . Gimenez-Lirola L. G., Xiao C. T., Halbur P. G., Journal of Microbiological Methods . 2012,第1期

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4. The spp biotech module 1: proteins for amedical applications a multidisciplinary effort for the development of a recombinant anti-RhD antibody preparation for the prevention of Hemolytic Disease of the Newborn [C] . H.AMSTUTZ, S.MIESCHER, R.MOUDRY Annual Meeting of the European Society of Animal Cell Technology . 1999

机译：SPP Biotech模块1：用于AMEDICY应用的蛋白质，用于开发重组抗RHD抗体制剂的多学科努力，用于预防新生儿的溶血性疾病
5. Development and application of an indirect ELISA for the detection of antibodies to porcine epidemic diarrhea virus based on a recombinant spike protein [O] . Huixing Lin, Hong Zhou, Lu Gao, 2018

机译：基于重组刺突蛋白的猪流行性腹泻病毒抗体间接ELISA的开发和应用
6. Development of passive immunization against periodontal disease: Preparations of recombinant ScFv and human type antibodies. [O] . Yoshimitsu Abiko 1998

机译：牙周病被动免疫的发展：重组SCFV和人类抗体的制剂。

The spp biotech module 1: proteins for amedical applications a multidisciplinary effort for the development of a recombinant anti-RhD antibody preparation for the prevention of Hemolytic Disease of the Newborn

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