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首页> 外文会议>International Conference on Raman Spectroscopy >An Experimental And Theoretical Raman and ROA Study Of Di-amino Acid Peptides (DAAPs): a- and fl-N-acetyl-L-Asp-L-Glu And Their Derivatives: N-acetyl-L-Asp, N-acetyl-L- Glu and L-Asp-L-Glu
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An Experimental And Theoretical Raman and ROA Study Of Di-amino Acid Peptides (DAAPs): a- and fl-N-acetyl-L-Asp-L-Glu And Their Derivatives: N-acetyl-L-Asp, N-acetyl-L- Glu and L-Asp-L-Glu

机译：二氨基酸肽（DAAPS）的实验和理论拉曼和ROA研究：A-和FL-N-乙酰基-L-ASP-L-Glu及其衍生物：N-乙酰基-L-ASP，N-乙酰基 - l-glu和l-asp-l-glu

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We have used Raman Optical Activity (ROA), which measures a small difference in Raman scattering by chiral molecules using left- and right-circularly polarized scattered light, to investigate the solution structures of glutamate and aspartate containing DAAPs. a-N-acetyl-L-Asp-L-Glu (a-NAAG) is the most commonly naturally occurring DAAP in the vertebrate central nervous system [1] and its biological activity as an excitory neurotransmitter, anti-histamine and mass cell de-granulator have been extensively researched [2]. β-N-acetyl-L-Asp-L-Glu (β-NAAG) has been implicated in neuropsychiatric disorders [3], while N-acetyl-L-Asp and Nacetyl-L-Glu are neurotransmitters in the brain [4, 5 and 6].
机译：我们使用了使用左右圆形偏振散射光的手性分子测量拉曼散射的拉曼光学活性（ROA），以研究谷氨酸和天冬氨酸的溶液结构。 An-acetyl-l-Asp-l-glu（a-naag）是脊椎动物中枢神经系统中最常见的天然存在的Daap [1]及其生物活性作为杂志神经递质，抗组胺和大规模细胞去造粒机已被广泛研究[2]。 β-N-乙酰基-1-ASP-L-Glu（β-NaAg）在神经精神疾病中涉及[3]，而N-乙酰基-L-ASP和甲炔-L-Glu是脑中的神经递质[4， 5和6]。

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