The solubilisation of some hydrophobic drugs using tapered statistical block copolymers.

机译：使用锥形统计嵌段共聚物的一些疏水性药物的溶解。

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The ability of poly(oxyalkylene) (POA) block copolymers to form micelles at low concentration has led to these structures being studied for their potential as carriers for novel and existing drugs~1. The amphiphilic nature of POA copolymers also allows them to circulate in the body for extended periods as a result of their avoidance of the reticuloendothelial system (RES)~2. POA copolymers also have potential in the solubilisation of hydrophobic drug substances and have been investigated for use in drug delivery forms~3. However, traditional diblock and triblock POA copolymer micelles have been found to be relatively poor solubilisers, a characteristic which has been attributed to the location of solubilised drugs at the hydrophobic/hydrophilic interface~4, and to their small size.

机译：聚（氧化烯）（POA）嵌段共聚物在低浓度下形成胶束的能力导致这些结构用于其作为新颖和现有药物的载体〜1的载体。 POA共聚物的两亲性质也允许它们在避免网状内皮系统（RES）〜2的结果中延长时期在体内循环。 POA共聚物还具有潜在的疏水性药物物质的溶解，并且已经研究用于药物递送形式〜3。然而，已经发现传统的二嵌段和三嵌段POA共聚物胶束是相对较差的溶解剂，这是归因于疏水/亲水界面〜4的溶解药物的位置的特征，以及它们的小尺寸。

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《International symposium on controlled release of bioactive materials》|2000年||共2页
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M.J.Quinn; J.H.Collett; D.Attwood; C.Booth; L.G.Martini; M.McAllister; P.L.Smith;
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中图分类生物材料学;
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1. Block copolymers for drug solubilisation: Relative hydrophobicities of polyether and polyester micelle-core-forming blocks. [J] . Attwood D, Booth C, Yeates SG, International Journal of Pharmaceutics . 2007,第1a2期

机译：用于药物增溶的嵌段共聚物：聚醚和形成聚酯胶束核心的嵌段的相对疏水性。
2. Nanoscopic core-shell drug carriers made of amphiphilic triblock and star-diblock copolymers. [J] . Quaglia F, Ostacolo L, De Rosa G, International Journal of Pharmaceutics . 2006,第1期

机译：由两亲性三嵌段和星形二嵌段共聚物制成的纳米级核壳药物载体。
3. Amphiphilic Triblock Copolymers from Poly(2-oxazoline) with Different Hydrophobic Blocks: Changes of the Micellar Structures upon Addition of a Strongly Hydrophobic Cancer Drug [J] . Jaksch Sebastian, Schulz Anita, Di Zhenyu, Macromolecular chemistry and physics . 2016,第13期

机译：聚（2-恶唑啉）具有不同疏水性嵌段的两亲性三嵌段共聚物：添加强疏水性癌症药物后胶束结构的变化
4. The solubilisation of some hydrophobic drugs using tapered statistical block copolymers. [C] . M.J.Quinn, J.H.Collett, D.Attwood, International symposium on controlled release of bioactive materials . 2000

机译：使用锥形统计嵌段共聚物的一些疏水性药物的溶解。
5. The application of liposomes for solubilisation of hydrophobic drugs. [D] . Leigh, Mathew Louis Steven. 1997

机译：脂质体在疏水药物增溶中的应用。
6. Synthesis Self-Assembly and Drug Delivery Characteristicsof Poly(methyl caprolactone-co-caprolactone)-b-poly(ethylene oxide) Copolymers with Variable Compositionsof Hydrophobic Blocks: Combining Chemistry and Microfluidic Processingfor Polymeric Nanomedicines [O] . Zheqi Xu, Changhai Lu, Carly Lindenberger, 2017

机译：合成自组装和药物输送特性可变组成的聚（甲基己内酯-共己内酯）-b-聚环氧乙烷共聚物疏水性嵌段的组合：化学与微流体加工相结合用于高分子纳米药物
7. Preparation of block and graft copolymers and their applications. VI. Synthesis and applications of hydrophilic and hydrophobic block copolymers. [O] . Hiroshi OHMURA, Hideki DOHYA, Yoshihiro OSHIBE, 1988

机译：嵌段和接枝共聚物的制备及其应用。 VI。亲水性和疏水嵌段共聚物的合成与应用。
8. Water-Soluble Copolymers. 53. (23)Na NMR Studies of Hydrophobically-ModifiedPolyacids: Copolymers of 2-(1-Naphthylacetamido) ethylacrylamide with Acrylic Acid and Methacrylic Acid [R] . Newman, J. K., McCormick, C. L. 1994

机译：水溶性共聚物。 53.（23）疏水改性多酸的Na NmR研究：2-（1-萘基乙酰氨基）乙基丙烯酰胺与丙烯酸和甲基丙烯酸的共聚物

The solubilisation of some hydrophobic drugs using tapered statistical block copolymers.

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