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Solid lipid nanoparticles (sln) as alternative delivery system

机译：固体脂质纳米颗粒（SLN）作为替代输送系统

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Since the beginning of the nineties an increasing interest has focused on nanoparticles made from solid lipids - solid lipid nanoparticles (SLN)~1. They represent an alternative to the traditional colloidal drug carriers emulsions, liposomes and polymeric nanoparticles combining their advantages and avoiding some disadvantages. Similar to polymeric nanoparticles they possess a solid matrix protecting incorporated active ingredients and allowing modification of the release profiel. Similar to emulsions and liposomes they are composed of well tolerated excipients and can be produced on large scale - thus overcoming the lack of suitable large scale production methods being a problem for polymeric nanoparticles. The increasing number of research groups world-wide working with SLN~1-4 reflects the growing interest in this technology. This paper reviews the present state of art of SLN technology and highlights future perspectives.
机译：由于九十年代的开始，越来越兴趣的兴趣重点是由固体脂质 - 固体脂质纳米颗粒（SLN）〜1制成的纳米颗粒。它们代表了传统的胶体药物载体乳液，脂质体和聚合物纳米颗粒的替代方案，这些优点结合起来并避免了一些缺点。与聚合物纳米颗粒类似，它们具有固体基质保护掺入的活性成分并允许修饰释放强制。类似于乳液和脂质体，它们由耐腐蚀性赋形剂组成，并且可以大规模生产 - 因此克服了缺乏合适的大规模生产方法是聚合物纳米颗粒的问题。越来越多的研究群体与SLN〜1-4一起使用，反映了对这项技术的兴趣日益增长。本文评论了目前的SLN技术艺术状态，并突出了未来的观点。

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