Intersolubility of lipids within solid lipid nanoparticles

机译：固体脂质纳米颗粒内脂质的渗透性

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Drug solubility is one of the main limiting factor in the desing of new carrier systems. Encapsulation of poorly soluble drugs within carriers is addressed through the formation and characterisation of cholesterol-containing solid triglyceride nanoparticles. Cholesterol (chol0 is nearly insoluble in water and only weakly soluble into organic solvents and lipids (1). Its weak solubility makes it a good candidate as a model for insoluble drug molecule. Cholesterol-contai-ning solid lipid nanoparticles and cholesterol solubility in trilaurin were studied.

机译：药物溶解度是新型载体系统的设计中的主要限制因素之一。通过含胆固醇的固体甘油三酯纳米颗粒的形成和表征来解决载体内稳定的药物的封装。胆固醇（Chol0几乎不溶于水中，只能易溶于有机溶剂和脂质（1）。其弱溶解性使其成为不溶性药物分子的模型的良好候选性。胆固醇 - 含有脂质纳米粒子和三叶仑胆固醇溶解度研究过。

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《International symposium on controlled release of bioactive materials》|2000年||共2页
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C.Allais; F.Arztner; S.Lesieur; M.Ollivon;
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中图分类生物材料学;
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Intersolubility of lipids within solid lipid nanoparticles

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