• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Annual Convention of the American Association of Equine Practitioners >Evaluation of the Efficacy Provided by a Recombinant Canarypox-Vectored Equine West Nile Virus Vaccine Against an Experimental West Nile Virus Intrathecal Challenge in Horses
【24h】

Evaluation of the Efficacy Provided by a Recombinant Canarypox-Vectored Equine West Nile Virus Vaccine Against an Experimental West Nile Virus Intrathecal Challenge in Horses

机译：评估重组Canarypox的疗效，将马西尼亚尼罗河病毒疫苗对马匹的实验西尼罗河病毒鞘内挑战进行评估

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The efficacy of a recombinant canarypox-vectored equine West Nile Virus (WNV) vaccinea was evaluated in a WNV disease model in horses by intrathecal administration of virulent WNV. Ten horses received two doses of a commercial serial of vaccine by theintramuscular route on days 0 and 35, and ten horses were held as unvaccinated controls. Horses were challenged with virulent WNV by intrathecal administration under general anesthesia on day 49. After challenge, eight of ten controls developed clinicalsigns of encephalomyelitis, whereas one vaccinate exhibited muscle fas-ciculation in one observation. Fever was present in nine controls and one vaccinate. Histopathol-ogy revealed mild to moderate non-suppurative encephalitis in eight controls and onevaccinate. All of the controls and none of the vaccinates had detectable post-challenge WNV viremia. These and the results of previous studies show the efficacy of this vaccine in horses against WNV-induced clinical disease and natural challenge with WNV-infected mosquitoes.
机译：通过鞘内施用毒力WNV在马匹中的WNV疾病模型中评估重组Canarypox-载体的大尼罗河病毒（WNV）疫苗的疗效。 10马以0和35天的intramuscular途径接受了两种商业连续的疫苗，并将十匹马作为未接触的控制。在第49天，在全身麻醉下，鞘内给药在毒力管理中挑战了毒性的。在挑战后，十个对照中的八个对脑脊髓炎的临床称为临床标志，而一个疫苗在一次观察中呈现肌肉缩编。发烧存在于九次对照中，一个接种疫苗。组织养老肠ogy在八个对照和一致中揭示了轻度至中等的非化脓性脑炎。所有对照和疫苗疫苗都没有检测到的攻击后WNV病毒血症。以前研究的这些和结果表明，这种疫苗在马上对WNV诱导的临床疾病和自然挑战的疗效与WNV感染的蚊子中的疗效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号