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首页> 外文期刊>Veterinary Therapeutics >Evaluation of the efficacy provided by a Recombinant Canarypox-Vectored Equine West Nile Virus vaccine against an experimental West Nile Virus intrathecal challenge in horses
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Evaluation of the efficacy provided by a Recombinant Canarypox-Vectored Equine West Nile Virus vaccine against an experimental West Nile Virus intrathecal challenge in horses

机译：评估金丝雀痘病毒载体马西尼罗河病毒重组疫苗对马实验性西尼罗河病毒鞘内攻击的功效

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摘要

Efficacy of the Recombitek Equine West Nile Virus (WNV) vaccine was evaluated against a WNV intrathecal challenge model that results in WNV-induced clinical disease. Ten vaccinated (twice at days 0 and 35) and 10 control horses were challenged 2 weeks after administration of the second vaccine with a virulent WNV by intrathecal administration. After the challenge, eight of 10 controls developed clinical signs of encephalomyelitis whereas one vaccinate exhibited muscle fasciculation only once. Nine controls and one vaccinate developed a fever. Histopathology revealed mild to moderate nonsuppurative encephalitis in eight controls and one vaccinate. None of the vaccinates and all of the controls developed WNV viremia after challenge. All vaccinated horses developed antibodies to WNV after vaccination. These and results of previous studies demonstrate efficacy of the Recombitek WNV vaccine against WNV-induced clinical disease and natural challenge with WNV-infected mosquitoes.
机译：针对导致WNV诱发的临床疾病的WNV鞘内攻击模型评估了Recombitek马西尼罗河病毒（WNV）疫苗的功效。在第二种疫苗接种后，通过鞘内给药，用强力WNV攻击10匹疫苗（在0和35天两次）和10匹对照马。攻击后，十名对照中有八名发展为脑脊髓炎的临床体征，而一剂疫苗仅表现出一次肌肉絮凝。九名对照组和一名接种者发烧。组织病理学检查显示8名对照和1名接种者有轻度至中度非化脓性脑炎。攻击后，没有疫苗和所有对照都发展出WNV病毒血症。接种疫苗后，所有接种马匹均产生针对WNV的抗体。这些和以前的研究结果表明，Recombitek WNV疫苗可有效抵抗WNV引起的临床疾病和感染WNV的蚊子的自然攻击。

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