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Relation between restriction modification genes and genome rearrangements suggested from genome sequence comparison within genus neisseria

机译：基因组序列比较中的限制性修饰基因与基因组重排之间的关系在奈瑟氏宫内的基因组序列比较

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Restriction-modification (RM) gene complexes, such as EcoRI, encode two enzymatic functions, restriction and rnodificatioa. A restriction enzyme will recognize a specific sequence in DNA and cut the DNA unless it is methylated by a cognate modification enzyme. RM systems will defend bacterial cells by attacking incoming foreign DNA. It is widely held that bacteria have evolved RM systems and maintain them in order to protect their genome from invasion by foreign DNA such as bacteriophages and plasmids. We found that a type II RM gene complex cannot be easily replaced by a competitor genetic element because cells that have lost the RM gene complex die through restriction enzyme attack on the chromosome. Prom this and other observations, we hypothesized that the relative frequency of RM gene complexes has increased through this post-segregational killing, in competitive exclusion, as well as through direct attack on invading DNA. The RM gene complexes are worth the name of selfish genes in the sense used in genetics and evolutionary biology.
机译：限制性修饰（RM）基因复合物，例如EcoRI，编码两种酶促功能，限制性和RNODIficatiOA。限制酶将识别DNA中的特定序列并切割DNA，除非它通过同源改性酶甲基化。 RM系统将通过攻击来源的外国DNA来保护细菌细胞。众所周知，细菌已经进化了RM系统并维持它们以保护其基因组免受异物DNA（例如噬菌体和质粒）的侵袭。我们发现，II型RM基因复合物不能容易地由竞争对手遗传因素代替，因为通过对染色体的限制酶攻击失去RM基因复合物的细胞。促销此类和其他观察结果，我们假设RM基因复合物的相对频率通过这种后勤杀伤，竞争排斥，以及通过直接攻击对入侵DNA进行直接攻击。 RM基因复合物在遗传学和进化生物学中使用的意义上是自私基因的名称。

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