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Comparative genomics begins to unravel the ecophysiology of Bioleaching

机译：比较基因组学开始解开生物浸出的生态学

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The metabolic potential of 16 bioleaching microorganisms (Eubacteria and Archaea) has been investigated, allowing the prediction of potential inter- and intra-species physiological interactions (ecophysiology) during spatial and temporal changes that are known to occur within industrial bioleaching heaps. Genome analysis has allowed preliminary models to be built for genes and pathways involved in key processes such as nitrogen and carbon cycling, sulfur and iron uptake and homeostasis, extra-cellular polysaccharide biosynthesis, heavy metal resistance and energy metabolism. This paper will focus on the diverse ways that microorganisms obtain carbon from their environment with a particular emphasis on elucidating how these processes might be expected to vary over space and time during the lifetime of a bioleaching operation. It is anticipated that this knowledge will improve our understanding of fundamental biological processes in extremely acidic environments and it is hoped that it will capture usable knowledge that can be applied to bioleaching. Comparative genomics between two strains of Acidthiobacillus ferrooxidans highlights the importance of lateral gene transfer in increasing genetic and metabolic potential and suggests that classical molecular DNA techniques, such as rDNA typing, significantly underestimate the microbial diversity of bioleaching heaps.
机译：研究了16种生物浸出微生物（噬菌体和archaea）的代谢潜力，从而在众所周知的空间和时间变化期间预测潜在和内外生理学间相互作用（生态学），该潜在的生物改变是在工业生物生物浸交堆内发生的。基因组分析允许为涉及氮气和碳循环，硫和铁吸收和稳态，细胞间多糖的关键过程中涉及的基因和途径构建初步模型，细胞多糖生物合成，重金属抗性和能量代谢。本文将重点关注微生物从其环境中获得碳的多样化方式，特别强调阐明这些过程如何在生物浸出操作的寿命期间可以在空间和时间内变化。预计这一知识将改善我们对极其酸性环境中基本生物过程的理解，希望它能够捕获可用于生物浸出的可用知识。两种菌株之间的比较基因组学刺激性酸辛酸辛烷瘤之间的重要性横向基因转移在增加遗传和代谢潜力时，表明典型的分子DNA技术，例如RDNA键入，显着低估了生物浸出堆的微生物多样性。

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