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首页> 外文期刊>Frontiers in Microbiology >Comparative Genomics Unravels the Functional Roles of Co-occurring Acidophilic Bacteria in Bioleaching Heaps
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Comparative Genomics Unravels the Functional Roles of Co-occurring Acidophilic Bacteria in Bioleaching Heaps

机译：比较基因组学揭示了生物浸提堆中共生嗜酸细菌的功能作用。

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The spatial-temporal distribution of populations in various econiches is thought to be potentially related to individual differences in the utilization of nutrients or other resources, but their functional roles in the microbial communities remain elusive. We compared differentiation in gene repertoire and metabolic profiles, with a focus on the potential functional traits of three commonly recognized members ( Acidithiobacillus caldus, Leptospirillum ferriphilum , and Sulfobacillus thermosulfidooxidans ) in bioleaching heaps. Comparative genomics revealed that intra-species divergence might be driven by horizontal gene transfer. These co-occurring bacteria shared a few homologous genes, which significantly suggested the genomic differences between these organisms. Notably, relatively more genes assigned to the Clusters of Orthologous Groups category [G] (carbohydrate transport and metabolism) were identified in Sulfobacillus thermosulfidooxidans compared to the two other species, which probably indicated their mixotrophic capabilities that assimilate both organic and inorganic forms of carbon. Further inspection revealed distinctive metabolic capabilities involving carbon assimilation, nitrogen uptake, and iron-sulfur cycling, providing robust evidence for functional differences with respect to nutrient utilization. Therefore, we proposed that the mutual compensation of functionalities among these co-occurring organisms might provide a selective advantage for efficiently utilizing the limited resources in their habitats. Furthermore, it might be favorable to chemoautotrophs' lifestyles to form mutualistic interactions with these heterotrophic and/or mixotrophic acidophiles, whereby the latter could degrade organic compounds to effectively detoxify the environments. Collectively, the findings shed light on the genetic traits and potential metabolic activities of these organisms, and enable us to make some inferences about genomic and functional differences that might allow them to co-exist.
机译：人们认为，各个生态圈中种群的时空分布可能与养分或其他资源利用中的个体差异有关，但它们在微生物群落中的功能作用仍然难以捉摸。我们比较了基因库和代谢谱的差异，重点是在生物浸提堆中三个常见的成员（嗜酸性酸杆菌，轻链螺旋体和热硫氧化亚砜）的潜在功能性状。比较基因组学表明，物种间的差异可能是由水平基因转移驱动的。这些共生细菌共享一些同源基因，这明显表明了这些生物之间的基因组差异。值得一提的是，与其他两个物种相比，在热硫氧化亚砜中鉴定出的属于直系同源簇类别[G]（碳水化合物转运和代谢）的基因相对较多，这可能表明它们具有同养能力，可以同化有机和无机形式的碳。进一步的检查显示了独特的代谢能力，包括碳同化，氮吸收和铁硫循环，为营养物利用方面的功能差异提供了有力的证据。因此，我们建议这些共同存在的生物之间功能的相互补偿可能为有效利用其栖息地中的有限资源提供选择优势。此外，可能有利于化学自养生物的生活方式与这些异养和/或混养嗜酸菌形成相互影响，从而后者可以降解有机化合物以有效地使环境解毒。总的来说，这些发现揭示了这些生物的遗传特征和潜在的代谢活性，并使我们能够推断出可能允许它们共存的基因组和功能差异。

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